Renal injury in obese Zucker rats: glomerular hemodynamic alterations and effects of enalapril.
Renal injury in obese Zucker rats: glomerular hemodynamic alterations and effects of enalapril.
复制标题
肥胖 Zucker 大鼠的肾损伤：肾小球血流动力学改变和依那普利的影响。
DOI：
10.1152/ajprenal.1992.263.3.f496
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Keane,WF
中科院分区：
文献类型：
--
作者：
Schmitz,PG;O'Donnell,MP;Kasiske,BL;Katz,SA;Keane,WF
血管紧张素转换酶抑制剂可以通过血流动力学或非血流动力学机制改善实验性肾小球损伤。在一项长期研究中，我们检查了 30 周依那普利治疗对肥胖 Zucker 大鼠 (OZR) 肾小球疾病发展的影响。在整个实验期间，依那普利显着（P 小于 0.05）降低血压、空腹血清胆固醇和 OZR 尿白蛋白排泄。在 38 周龄时，依那普利治疗的 OZR 使表现出局灶性肾小球硬化的肾小球百分比减少了六倍，肾脏重量和肾小球面积减少了 20-30%。对 22 至 26 周龄大鼠进行的一项单独的微穿刺研究表明，未经治疗的 OZR 伴蛋白尿和血压升高会导致肾小球毛细血管压力 (Pgc) 升高。依那普利治疗的 OZR 具有较少的蛋白尿和较低的血压，但 Pgc 并未降低。依那普利治疗的 OZR 中的跨毛细血管液压差 (delta P) 值介于未治疗的 OZR 和瘦 Zucker 大鼠的值之间。因此，依那普利显着减轻了 OZR 中肾小球损伤的发展。依那普利的有益作用可能涉及与非血流动力学作用相结合的 delta P 降低，可能限制肾小球生长或降低血清胆固醇。
Angiotensin-converting enzyme inhibitors may ameliorate experimental glomerular injury by either hemodynamic or nonhemodynamic mechanisms. In a long-term study, we examined the effects of 30 wk of enalapril treatment on the development of glomerular disease in obese Zucker rats (OZR). Enalapril significantly (P less than 0.05) lowered blood pressure, fasting serum cholesterol, and urine albumin excretion in OZR throughout the experimental period. At 38 wk of age, enalapril-treated OZR had a sixfold reduction in the percent glomeruli exhibiting focal glomerulosclerosis and a 20-30% reduction in kidney weight and glomerular area. A separate micropuncture study in 22- to 26-wk-old rats revealed that untreated OZR with albuminuria and increased blood pressure had elevated glomerular capillary pressure (Pgc). Enalapril-treated OZR had less albuminuria and lower blood pressure, but Pgc was not reduced. The value of the transcapillary hydraulic pressure difference (delta P) in enalapril-treated OZR was intermediate between values in untreated OZR and lean Zucker rats. Thus enalapril markedly attenuated the development of glomerular injury in OZR. The salutary effects of enalapril may have involved a reduction in delta P coupled to a nonhemodynamic action, possibly restriction of glomerular growth or lowering of serum cholesterol.