Frequency distribution of HCV genotypes among chronic hepatitis C patients of Khyber Pakhtunkhwa.
Frequency distribution of HCV genotypes among chronic hepatitis C patients of Khyber Pakhtunkhwa.
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DOI：
10.1186/1743-422x-8-193
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发表时间：
2011-04-26
期刊：
影响因子：
4.8
通讯作者：
Ahmad B
中科院分区：
文献类型：
--
作者：
Ali S;Ali I;Azam S;Ahmad B
丙型肝炎病毒（HCV）基因型频率对预测治疗反应和治疗持续时间很重要。尽管在基于干扰素（IFN）的治疗中出现了不同的应答率，但开伯尔-普赫图赫瓦省（KPK）的HCV基因型频率数据很少。在开始抗病毒治疗之前，从慢性HCV患者中收集了总共200份血液样本。研究人群包括来自KPK 6个区的患者。所有患者均经真实的时间PCR检测证实为活动性HCV感染。HCV基因型在每种情况下，通过类型特异性PCR确定。200例PCR阳性标本中，2a型78例（39%），3a型62例（31%），3b型16例（8%），34例（17%）无法分型，1a型3例（1.5%），2b型2例（1%），1b型5例（2.5%）。KPK治疗前不进行基因型测定。尽管KPK中大量流行的HCV类型（2a和3a）对联合治疗敏感，但一些慢性HCV患者中出现的耐药可能部分归因于人群中HCV耐药基因型（1a，1b）的流行率较低。
Hepatitis C Virus (HCV) genotypes frequency is important for the predication of response to therapy and duration of treatment. Despite variable response rates experienced in the case of Interferon (IFN) -based therapies, there was scarcity of data on HCV genotypes frequency in Khyber Pakhtunkhwa (KPK). A total of 200 blood samples were collected from chronic HCV patients prior to the initiation of anti-viral therapy. The study population included patients from 6 districts of KPK. Active HCV infection was confirmed in case of all the patients by real time PCR. HCV genotypes were determined in each case by Type-specific PCR. The analysis revealed that out of 200 PCR positive samples; 78 (39%) were 2a, 62 (31%) were 3a, 16 (8%) were 3b, 34 (17%) were untypable while 1a, 2b and 1b were 3 (1.5%), 2 (1%) and 5 (2.5%), respectively. Genotype determination is not carried out prior to therapy in KPK. Although, the abundantly prevalent types (2a and 3a) of HCV in KPK are susceptible to combination therapy, yet resistance experienced in some of the chronic HCV patients may partly be attributed to the prevalence of less prevalent resistant genotypes (1a, 1b) of HCV among the population.