Comparative Responses of the Carotid and Vertebral Arterial Systems of Rhesus Monkeys to. Betahistine
Comparative Responses of the Carotid and Vertebral Arterial Systems of Rhesus Monkeys to. Betahistine
复制标题
恒河猴颈动脉和椎动脉系统的比较反应。
DOI：
10.1161/01.str.9.4.382
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发表时间：
1978
期刊：
影响因子：
8.3
通讯作者：
Masahiro Yamamoto
中科院分区：
文献类型：
--
作者：
M. Tomita;Fumio Gotoh;T. Sato;Takahiro Amano;N. Tanahashi;Kanta Tanaka;Masahiro Yamamoto
本文用光电法测量了5只猕猴颈动脉和椎动脉的平均通过时间，并测量了颈动脉供血额顶区和椎动脉供血小脑扁桃体的血流量。静脉注射组胺类似物倍他司汀后，尽管平均动脉血压降低20%，但血液通过两条动脉的平均通过时间同样缩短10%（P < 0.05）。脑组织和小脑组织血流量通过倍他司汀分别从70.4 ml/100 g/min增加至81.4 ml/100 g/min和从73.2 ml/100 g/min增加至84.0 ml/100 g/min。由于组胺已被报道产生心输出量的减少，脑血流量的增加证实了倍他司汀是一种选择性脑血管舒张剂。然而，通过比较两个脑动脉系统的血流动力学数据，可以得出结论，颈动脉和椎动脉系统对倍他司汀的血管舒张作用的反应在程度上基本相同。
A newly developed photoelectric method was used in 5 rhesus monkeys to measure the mean transit time of blood through the carotid and vertebral arteries, together with measurement of the blood flow through the tissues of the fronto-parietal area supplied by the carotid artery and of'the cerebellar tonsil supplied by the vertebral artery. Following intravenous administration of betahistine mesylate, a histamine analog, the mean transit times of blood through the 2 arteries were equally shortened by 10%, despite a 20% decrease in the mean arterial blood pressure (P < 0.05). The cerebral tissue and cerebellar tissue blood flow was increased by betahistine, from 70.4 to 81.4 ml/IOOg/min and from 73.2 to 84.0 ml/lOOg/min, respectively. Since histamine has been reported to produce a decrease'in cardiac output, the increase in cerebral blood flow confirmed that betahistine is a selective cerebral vasodilating agent. However, by comparing the hemodynamic data for the two cerebral arterial systems, it can be concluded that the responses of the carotid and vertebral arterial systems to the vasodilating action of betahistine were essentiallythe same in extent.