Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat
Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat
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DOI：
10.1016/0304-3835(95)90207-4
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发表时间：
1995-11-27
期刊：
影响因子：
9.7
通讯作者：
Chou, CK
中科院分区：
文献类型：
--
作者：
Moore, JC;Lai, H;Chou, CK
在铁存在的情况下，双氢青蒿素会形成自由基并导致细胞死亡。由于大多数癌细胞对铁的摄取率很高，双氢青蒿素对癌细胞具有选择性的细胞毒作用。本实验旨在研究双氢青蒿素和硫酸亚铁对大鼠移植性纤维肉瘤生长的影响。我们发现，每天口服硫酸亚铁和双氢青蒿素可显著延缓肿瘤的生长速度。在双氢青蒿素或硫酸亚铁单独治疗的大鼠中，没有观察到明显的肿瘤生长抑制作用。与未经治疗的肿瘤移植动物相比，药物治疗对体重没有明显影响，药物治疗后也没有明显的毒性反应。青蒿素类似物与亚铁盐的结合可能为癌症治疗提供一种新的方法。
In the presence of iron, dihydroartemisinin forms free radicals and causes cell death. Since most cancer cells have high rates of iron intake, dihydroartemisinin would have selective cytotoxic effect on cancer cells. The present experiment was designed to study the effect of dihydroartemisinin and ferrous sulfate on the growth of implanted fibrosarcoma in the rat. We found that the growth rate of the tumor was significantly retarded by daily oral administration of ferrous sulfate followed by dihydroartemisinin. No significant tumor growth retardation effect was observed in rats treated with either dihydroartemisinin or ferrous sulfate alone. The drug treatment did not significantly affect body weight compared with untreated tumor-implanted animals and no apparent toxic effect was observed after drug treatment. An artemisinin analog-ferrous salt combination may provide a novel approach for cancer therapy.