Fixation indices in subdivided populations.
Fixation indices in subdivided populations.
复制标题
细分群体中的注视指数。
作者：
T. Nagylaki
在不限制可能存在的进化力量的情况下，在任意细分的群体中，固定指数或F统计量的理论是根据等位基因和基因型频率系统地发展起来的。每个纯合基因型的固定指数以杂合基因型的固定指数表示。因此，与等位基因频率一起，后者足以描述群体结构。等位基因频率中可能的随机波动（这可能是由，例如，由有限的亚群）被纳入，使固定指数的参数，而不是随机变量，这些参数表示的杂合性的进化预期的比率。还讨论了种群分化的一些措施的解释。特别是，F（ST）是一个合适的指标基因频率分化当且仅当遗传多样性低。
Without restricting the evolutionary forces that may be present, the theory of fixation indices, or F-statistics, in an arbitrarily subdivided population is developed systematically in terms of allelic and genotypic frequencies. The fixation indices for each homozygous genotype are expressed in terms of the fixation indices for the heterozygous genotypes. Therefore, together with the allelic frequencies, the latter suffice to describe population structure. Possible random fluctuations in the allelic frequencies (which may be caused, e.g., by finiteness of the subpopulations) are incorporated so that the fixation indices are parameters, rather than random variables, and these parameters are expressed in terms of ratios of evolutionary expectations of heterozygosities. The interpretation of some measures of population differentiation is also discussed. In particular, F(ST) is an appropriate index of gene-frequency differentiation if and only if the genetic diversity is low.