Biological therapy of breast cancer: recent clinical applications.
Biological therapy of breast cancer: recent clinical applications.
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乳腺癌的生物治疗：最近的临床应用。
DOI：
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发表时间：
2007
影响因子：
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通讯作者：
J. Baar
中科院分区：
文献类型：
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作者：
J. Baar
乳腺癌的治疗已经取得了进展，包括辅助治疗和转移治疗。例如，在辅助剂环境中，对乳腺癌组织的基因组研究发现，患有雌激素受体阳性肿瘤的女性可能不需要化疗，这导致了诊断工具的开发。针对肿瘤细胞表面受体的抗癌药也取得了重大进展，如HER2/neu，以及那些参与血管生成和激酶依赖途径的抗癌药。新的研究领域集中在乳腺癌干细胞的概念以及早期乳腺癌骨髓微转移的预后重要性上。本文就乳腺癌的临床研究进展作一综述。
Advances have been made in breast cancer therapy, in both the adjuvant and metastatic settings. For example, in the adjuvant setting, genomic studies of breast cancer tissues have identified women with estrogen receptor-positive tumors who might not require chemotherapy, leading to the development of a diagnostic tool. There have also been significant developments with anticancer agents that target tumor cell surface receptors, such as HER2/neu, and those involved in angiogenesis and kinase-dependent pathways. New areas of research focus on the concept of breast cancer stem cells as well as the prognostic importance of bone marrow micrometastases in early-stage breast cancer. This review summarizes these advances in breast cancer clinical research.