HYPERGLYCEMIC AND INSULIN RELEASE INHIBITORY EFFECTS OF ROSMARINUS-OFFICINALIS
HYPERGLYCEMIC AND INSULIN RELEASE INHIBITORY EFFECTS OF ROSMARINUS-OFFICINALIS
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DOI：
10.1016/0378-8741(94)90046-9
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发表时间：
1994-07-22
影响因子：
5.4
通讯作者：
AQEL, MB
中科院分区：
文献类型：
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作者：
ALHADER, AA;HASAN, ZA;AQEL, MB
采用腹腔葡萄糖耐量试验（GTT）研究了迷迭香叶挥发油对正常家兔葡萄糖和胰岛素水平的影响。同时，研究了挥发油对四氧嘧啶糖尿病家兔空腹血糖水平的影响。在正常家兔中，肌肉注射挥发油（25 mg/kg）使其血糖水平在腹腔注射后60min、90min和120min分别比对照组升高20% （P < 0.05）、27% （P < 0.01）和55% （P < 0.001）。与对照组相比，同样的处理也导致血清胰岛素水平在间隔30 min时下降30% （P < 0.002）。给药6 h后，四氧嘧啶糖尿病家兔空腹血糖水平较未给药家兔提高17% （P < 0.05）。上述结果提示，马地黄挥发油对家兔具有抑制高血糖和胰岛素释放的作用。
The effects of the volatile oil extracted from the leaves of Rosmarinus officinalis on glucose and insulin levels were investigated in normal rabbits, after the administration of an intraperitoneal glucose tolerance test (GTT). Also, the effects of the volatile oil on fasting plasma glucose levels, were studied in alloxan diabetic rabbits. In normal rabbits, the intramuscular (i.m.) administration of the volatile oil (25 mg/kg) produced 20% (P < 0.05), 27% (P < 0.01) and 55% (P < 0.001) increases in plasma glucose levels, above those of control animals, at the 60, 90 and 120 min intervals, respectively, following the administration of the intraperitoneal (i.p.) glucose test. The same treatment also resulted in a 30% (P < 0.002) decrease in serum insulin level, in comparison with that of control rabbits at the 30 min interval. In alloxan diabetic rabbits, R. officinalis volatile oil increased fasting plasma glucose levels by 17% (P < 0.05) above those of untreated animals 6 h after its administration. These data suggest that the volatile oil of R. officinalis has hyperglycemic and insulin release inhibitory effects in the rabbit.