The dual origin of the Malagasy in Island Southeast Asia and East Africa: Evidence from maternal and paternal lineages
The dual origin of the Malagasy in Island Southeast Asia and East Africa: Evidence from maternal and paternal lineages
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DOI：
10.1086/430051
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发表时间：
2005-05-01
影响因子：
9.8
通讯作者：
Forster, P
中科院分区：
文献类型：
--
作者：
Hurles, ME;Sykes, BC;Forster, P
关于马达加斯加土著民族马达加斯加人的起源，语言和考古学证据表明，他们的祖先是非洲人和印度尼西亚人的混合。相比之下，关于马达加斯加人起源的遗传学证据迄今为止仍然是部分的和不精确的。我们定义了26个Y染色体谱系分型44 Y染色体多态性在362名男性从四个不同的种族群体从马达加斯加和10个潜在的祖先群体在东南亚和太平洋岛屿。我们还比较了马达加斯加人的线粒体序列多样性与人工管理的19，371个高变片段I序列的数据库，包括已发表和未发表的数据。我们可以把在马达加斯加发现的每一个母系和父系血统归因于一个可能的地理起源。在这里，我们展示了非洲人和印度尼西亚人对马达加斯加父系和母系血统的贡献大致相等。在马达加斯加发现的源自亚洲的父系血统最有可能的起源是婆罗洲。这与语言学证据惊人地一致，即婆罗洲南部巴里托河周围的语言是马达加斯加语现存最接近的亲属。由于他们同样平衡的混合血统，马达加斯加人可能代表了一个理想的人口，以确定基因座潜在的人类学和医学利益的复杂特征。
Linguistic and archaeological evidence about the origins of the Malagasy, the indigenous peoples of Madagascar, points to mixed African and Indonesian ancestry. By contrast, genetic evidence about the origins of the Malagasy has hitherto remained partial and imprecise. We defined 26 Y-chromosomal lineages by typing 44 Y-chromosomal polymorphisms in 362 males from four different ethnic groups from Madagascar and 10 potential ancestral populations in Island Southeast Asia and the Pacific. We also compared mitochondrial sequence diversity in the Malagasy with a manually curated database of 19,371 hypervariable segment I sequences, incorporating both published and unpublished data. We could attribute every maternal and paternal lineage found in the Malagasy to a likely geographic origin. Here, we demonstrate approximately equal African and Indonesian contributions to both paternal and maternal Malagasy lineages. The most likely origin of the Asia-derived paternal lineages found in the Malagasy is Borneo. This agrees strikingly with the linguistic evidence that the languages spoken around the Barito River in southern Borneo are the closest extant relatives of Malagasy languages. As a result of their equally balanced admixed ancestry, the Malagasy may represent an ideal population in which to identify loci underlying complex traits of both anthropological and medical interest.