Using the St. George Respiratory Questionnaire to ascertain health quality in persons with treated pulmonary tuberculosis
Using the St. George Respiratory Questionnaire to ascertain health quality in persons with treated pulmonary tuberculosis
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DOI：
10.1378/chest.07-0755
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发表时间：
2007-11-01
期刊：
影响因子：
9.6
通讯作者：
Weis, Stephen E.
中科院分区：
文献类型：
--
作者：
Pasipanodya, Jotam G.;Miller, Thaddeus L.;Weis, Stephen E.
简介：肺结核（PTB）可导致解剖和功能变化，这些变化与肺结核后的肺损害相关，肺结核频繁发生且严重程度不同。我们完成了圣乔治呼吸问卷（SGRQ），这是一种健康相关的生活质量（HRQoL）工具，适用于诊断为PTB或潜伏性结核感染（LTBI）的患者。我们测量HRQoL模式的变化和实用性的SGRQ在其ascertainment.Methods：参与者与已知的肺功能和历史的PTB或LTBI完成HRQoL问卷。使用肺功能检查和医学结局研究问卷对SGRQ的内容和结构进行了验证。内部一致性和重测方法评估信度。研究结果的显著性用单因素方差分析与组间comparison.Results：在15个月内，313名受试者完成了SGRQ。SGRQ在研究人群中是有效和可靠的（组内相关性，0.927; p < 0.01; Cronbach α，0.93）。结核病后患者的平均总分显著高于LTBI评分（分别为23.5 [SE，2.2] vs 10.3 [SE，1.01; p < 0.001）。我们验证了SGRQ在不同人群中微生物学治愈的结核病，发现平均13.5-这些患者与具有相似危险因素的对照组之间SGRQ评分的差异无统计学意义（p < 0.001）。这一差异表明PTB后的损害对全球人类健康有重大影响。结核病的微生物疗法不足以避免慢性健康损失。全世界都需要更积极的LTBI治疗和其他病例预防策略。
Introduction: Pulmonary tuberculosis (PTB) can result in anatomic and functional changes that are associated with pulmonary impairment after tuberculosis that occurs frequently and varies in severity. We completed the St. George Respiratory Questionnaire (SGRQ), a health-related quality-of-life (HRQoL) instrument validated for several types of lung disease, for patients in whom PTB or latent tuberculosis infection (LTBI) has been diagnosed. We measured HRQoL pattern changes and the usefulness of the SGRQ in their ascertainment.Methods: Participants with known pulmonary function and a history of PTB or LTBI completed HRQoL questionnaires. The SGRQ was validated for content and construct using pulmonary function tests and the Medical Outcomes Study questionnaire. Internal consistency and test-retest methods assessed reliability. Significance of findings was determined with one-way analysis of variance with between-group comparisons.Results: Over 15 months, 313 subjects completed the SGRQ. The SGRQ was valid and reliable in the study population (intraclass correlation, 0.927; p < 0.01; Cronbach alpha, 0.93). The mean total score for posttuberculosis patients was significantly higher than for that for LTBI score (23.5 [SE, 2.2] vs 10.3 [SE, 1.01, respectively; p < 0.001).Conclusions: We validated the SGRQ in a diverse population microbiologically cured of tuberculosis and found a mean 13.5-U difference in SGRQ score between these patients and a comparison group with similar risk factors (p < 0.001). This difference indicates impairment after PTB has a substantial impact on human health worldwide. The microbiological cure of tuberculosis is not sufficient to avert chronic health loss. More aggressive treatment of LTBI and other case-preventing strategies is warranted worldwide.