Dual-Energy Parathyroid 4D-CT: Improved Discrimination of Parathyroid Lesions from Thyroid Tissue Using Noncontrast 40-keV Virtual Monoenergetic Images
Dual-Energy Parathyroid 4D-CT: Improved Discrimination of Parathyroid Lesions from Thyroid Tissue Using Noncontrast 40-keV Virtual Monoenergetic Images
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DOI：
10.3174/ajnr.a7265
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发表时间：
2021-09-02
影响因子：
3.5
通讯作者：
Sachs, J. R.
中科院分区：
文献类型：
--
作者：
Bunch, P. M.;Pavlina, A. A.;Sachs, J. R.
背景和目的：在甲状旁腺CT中，非增强相有助于区分甲状旁腺病变（不含碘）和甲状腺组织（含碘）。当甲状腺碘病理性减少时，标准CT很难鉴别。因为元素的衰减在其K边缘附近最大（碘？33.2？keV），我们假设双能量CT 40-keV虚拟单能图像将相对于标准图像突出甲状腺碘，提高甲状腺与甲状旁腺病变的鉴别。我们的目的是通过定量评估双能CT标准（70 keV）和40 keV非造影图像的Hounsfield单位衰减和对比度噪声来验证这一假设。材料和方法：对于这项回顾性研究，包括20个双能量甲状旁腺CT，我们使用了基于ROI的分析，以评估衰减的甲状腺组织，甲状旁腺病变，胸锁乳突肌以及相应的对比度噪声标准和40-？keV非对比图像。Wilcoxon符号秩检验进行比较70？40？凯结果：在40？keV甲状腺显著大于甲状旁腺病变和胸锁乳突肌（P？
BACKGROUND AND PURPOSE: In parathyroid CT, a noncontrast phase aids discrimination of parathyroid lesions (not iodine-containing) from thyroid tissue (iodine-containing). When thyroid iodine is pathologically diminished, this differentiation is difficult with standard CT. Because the attenuation of an element is maximal near its K-edge (iodine ?= 33.2?keV), we hypothesized that dual-energy CT 40-keV virtual monoenergetic images will accentuate thyroid iodine relative to standard images, improving the differentiation of thyroid from parathyroid lesions. Our purpose was to test this hypothesis through quantitative assessment of Hounsfield unit attenuation and contrast-to-noise on dual-energy CT standard (70-keV) and 40-keV noncontrast images. MATERIALS AND METHODS: For this retrospective study including 20 dual-energy parathyroid CTs, we used an ROI-based analysis to assess the attenuation of thyroid tissue, parathyroid lesions, and sternocleidomastoid muscle as well as corresponding contrast-to-noise on standard and 40-?keV noncontrast images. Wilcoxon signed rank tests were performed to compare differences between 70? and 40?keV. RESULTS: Absolute and percentage increases in attenuation at 40?keV were significantly greater for thyroid gland than for parathyroid lesions and sternocleidomastoid muscle (P?