Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia
Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia
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RASD1 转录水平在成人费城阴性 B 细胞急性淋巴细胞白血病中的预后价值
DOI：
10.1080/16078454.2020.1860359
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发表时间：
2020-12
期刊：
影响因子：
1.9
通讯作者：
Huang Xiao-Jun
中科院分区：
文献类型：
--
作者：
Lu Run-Qing;Wu Li-Xin;Zhang Jing;Qin Ya-Zhen;Liu Yan-Rong;Lai Yue-Yun;Jiang Hao;Chang Ying-Jun;Ruan Guo-Rui;Huang Xiao-Jun
摘要目的Ras相关的地塞米松诱导1（RASD 1）在许多实体癌中异常表达。然而，其在成人B细胞急性淋巴细胞白血病（B-ALL）中的潜在作用尚不清楚。因此，我们的目的是阐明肿瘤相关生物标志物RASD 1的异常表达，作为诊断和预后成人费城阴性B-ALL的潜在靶点。方法采用RT-qPCR方法检测92例初发Ph阴性B-ALL患者和40例健康对照者RASD 1的表达。评估RASD 1转录水平与复发之间的相关性。结果Ph阴性B-ALL患者RASD 1基因表达水平（中位数81.76%，0.22%~ 1824.52%）显著高于健康对照组（中位数7.59%，0.46%~ 38.66%）（P<0.0001）。RASD 1转录水平低的患者5年无复发生存率较低（RFS，47.5% [32.9%，62.1%] vs. 63.1% [49.0%，77.2%]; P = 0.012）和更高的5年累积复发率（CIR，52.0% [37.4%，66.6%] vs. 36.2% [22.2%，50.2%]; P = 0.013），尤其是在仅接受化疗的患者中。多因素分析显示，低RASD 1转录水平是Ph阴性B-ALL患者RFS（HR = 2.938 [1.427，6.047]，P = 0.003）和CIR（HR = 3.367 [1.668，6.796]，P = 0.001）的独立危险因素。结论Ph阴性B-ALL患者RASD 1转录水平显著升高，低RASD 1转录水平与复发风险增加独立相关。
ABSTRACT Objectives Ras-related dexamethasone-induced 1 (RASD1) is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, RASD1, as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL. Methods The expression of RASD1 was detected with RT-qPCR in 92 adults with de novo Ph-negative B-ALL and 40 healthy controls. The correlation between RASD1 transcript levels and relapse was assessed. Results RASD1 transcript levels in patients with Ph-negative B-ALL (median 81.76%, range 0.22%-1824.52%) were significantly higher than those in healthy controls (7.59%, 0.46%-38.66%; P<0.0001). Patients with low RASD1 transcript levels had a lower 5-year relapse-free survival (RFS, 47.5% [32.9%, 62.1%] vs. 63.1% [49.0%, 77.2%]; P = 0.012) and a higher 5-year cumulative incidence of relapse (CIR, 52.0% [37.4%, 66.6%] vs. 36.2% [22.2%, 50.2%]; P = 0.013) especially in patients receiving chemotherapy only. Multivariate analysis showed that a low RASD1 transcript level was an independent risk factor for RFS (HR = 2.938 [1.427, 6.047], P = 0.003) and CIR (HR = 3.367 [1.668, 6.796], P = 0.001) in patients with Ph-negative B-ALL. Conclusions RASD1 transcript levels were significantly higher in patients with Ph-negative B-ALL and a low RASD1 transcript level was independently correlated with increased relapse risk.
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