Nerve Growth Factor: A Focus on Neuroscience and Therapy.
Nerve Growth Factor: A Focus on Neuroscience and Therapy.
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DOI：
10.2174/1570159x13666150403231920
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发表时间：
2015
影响因子：
5.3
通讯作者：
Micera A
中科院分区：
文献类型：
--
作者：
Aloe L;Rocco ML;Balzamino BO;Micera A
神经生长因子（nerve growth factor，NGF）是最早发现的神经营养因子，对交感神经元、感觉神经元和前脑胆碱能神经元的发育和存活具有重要的保护作用。在体内和体外，神经生长因子促进神经炎的生长，以及缺血、手术或化学损伤后神经细胞的恢复。最近，已经证实了NGF对人类皮肤和角膜溃疡、压力性溃疡、青光眼、黄斑病变和视网膜色素变性的治疗特性。 NGF滴眼液给药耐受性良好，没有可检测到的全身或局部不良反应的临床证据。本文就神经生长因子的生物学特性及其临床应用前景作一综述。
Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis outgrowth both in vivo and in vitro and nerve cell recovery after ischemic, surgical or chemical injuries. Recently, the therapeutic property of NGF has been demonstrated on human cutaneous and corneal ulcers, pressure ulcer, glaucoma, maculopathy and retinitis pigmentosa. NGF eye drops administration is well tolerated, with no detectable clinical evidence of systemic or local adverse effects. The aim of this review is to summarize these biological properties and the potential clinical development of NGF.