Prognosis following first-time myocardial infarction in patients with psoriasis: a Danish nationwide cohort study
Prognosis following first-time myocardial infarction in patients with psoriasis: a Danish nationwide cohort study
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DOI：
10.1111/j.1365-2796.2011.02368.x
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发表时间：
2011-09-01
影响因子：
11.1
通讯作者：
Hansen, P. R.
中科院分区：
文献类型：
--
作者：
Ahlehoff, O.;Gislason, G. H.;Hansen, P. R.
首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容(哥本哈根大学医院，海勒鲁普；哥本哈根大学医院，罗斯基勒，丹麦)。牛皮癣患者首次心肌梗死后的预后：一项丹麦全国性队列研究。《实习生医学杂志》2011；270：237-244。与银屑病相关的心血管风险的大小一直存在争议，牛皮癣合并心肌梗死(MI)对预后的影响尚不清楚。因此，我们调查了银屑病患者首次心肌梗死后的死亡率和不良心血管事件的风险。设计、设置和参与者。对整个丹麦人口的队列研究，包括2002-2006年期间首次发生心肌梗死的所有个人。多变量COX回归模型用于评估心梗后银屑病的预后影响。全因死亡率和反复心肌梗死、中风和心血管死亡的复合心血管终点。在研究期间，共有462名银屑病患者和48935名对照(平均年龄分别为69.5岁和70.6岁)被确认为首次心肌梗死。银屑病患者平均随访19.5个月[标准差(SD)16.5]，非银屑病患者平均随访22.0个月(SD 18.7)。无银屑病患者和有银屑病患者的全因死亡率分别为119.4[95%可信区间(CI)117.2~138.3]和138.3(95%CI 114.1~167.7)，与银屑病相关的调整危险比(HR)为1.18(95%CI 0.97~1.43)。对于复合终点，非银屑病患者和银屑病患者的IR分别为149.7(95%CI 147.1-152.4)和185.6(95%CI 155.8-221.0)，而银屑病患者的IR为1.26(95%CI 1.04-1.54)。这项关于银屑病对首次心肌梗死后预后影响的首次研究表明，银屑病患者的预后明显受损。有必要对这种新的联系进行进一步的研究。
Ahlehoff O, Gislason GH, Lindhardsen J, Olesen JB, Charlot M, Skov L, Torp-Pedersen C, Hansen PR. (Copenhagen University Hospital Gentofte, Hellerup; Copenhagen University Hospital Roskilde, Roskilde, Denmark). Prognosis following first-time myocardial infarction in patients with psoriasis: a Danish nationwide cohort study. J Intern Med 2011; 270: 237-244.Objectives. The magnitude of cardiovascular risk associated with psoriasis has been debated and the prognostic impact of psoriasis following myocardial infarction (MI) is unknown. Therefore, we investigated the risk of mortality and adverse cardiovascular events in patients with psoriasis following first-time MI.Design, setting and participants. Cohort study of the entire Danish population including all individuals who experienced first-time MI during the period 2002-2006. Multivariable Cox regression models were used to assess the post-MI prognostic impact of psoriasis.Main outcome measures. All-cause mortality and a composite cardiovascular end-point of recurrent MI, stroke and cardiovascular death.Results. A total of 462 patients with psoriasis and 48 935 controls (mean age 69.5 and 70.6 years, respectively) were identified with first-time MI during the study period. The mean follow-up was 19.5 months [standard deviation (SD) 16.5] for patients with psoriasis and 22.0 months (SD 18.7) for those without psoriasis. Incidence rates (IRs) per 1000 patient-years for all-cause mortality were 119.4 [95% confidence interval (CI) 117.2-138.3] and 138.3 (95% CI 114.1-167.7) for patients without and with psoriasis, respectively, and the adjusted hazard ratio (HR) associated with psoriasis was 1.18 (95% CI 0.97-1.43). For the composite end-point, the IRs were 149.7 (95% CI 147.1-152.4) and 185.6 (95% CI 155.8-221.0) for patients without and with psoriasis, respectively, with an HR of 1.26 (95% CI 1.04-1.54) for patients with psoriasis.Conclusion. This first study of the impact of psoriasis on prognosis after first-time MI indicated a significantly impaired prognosis in patients with psoriasis. Further studies of this novel association are warranted.