Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices.
Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices.
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DOI：
10.1007/978-1-4939-1714-3_42
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hascall, Vincent C
中科院分区：
文献类型：
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作者：
Lauer, Mark E;Loftis, Jacqueline;de la Motte, Carol;Hascall, Vincent C
During inflammation and developmental processes, heavy chains (HCs) from inter-α-inhibitor (IαI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG- 6) to form a HC-HA complex. In this manuscript, we describe a gel-based assay to detect HC-HA and TSG-6 activity in tissues.
