Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis
Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis
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DOI：
10.1016/j.jid.2018.10.029
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发表时间：
2019-04-01
影响因子：
6.5
通讯作者：
Asgari, Maryam M.
中科院分区：
文献类型：
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作者：
Kim, Yuhree;Blomberg, Maria;Asgari, Maryam M.
虽然以前的研究探讨了儿童期特应性皮炎（AD）的种族/民族差异，但很少有研究探讨与AD持续相关的风险因素。因此，我们试图研究儿童AD的发病率和持续性的差异，种族/民族占社会人口学特征和围产期维生素D水平。使用来自Viva项目的数据，该项目是马萨诸塞州东部的一个前瞻性出生前队列，我们研究了1,437对已知AD状态的母子对，以检查种族/民族与母亲报告的儿童AD的关联。我们使用多变量logistic回归，调整社会人口因素和母亲血浆维生素D，以估计儿童早期AD发病率和儿童中期AD持续性的调整优势比（aOR）。与非西班牙裔白人相比，非西班牙裔黑人（aOR = 2.71，95%置信区间= 1.75-4.19）和其他非西班牙裔（aOR = 1.80，95%置信区间= 1.16-2.80）更有可能发生AD。患有早期儿童AD的非西班牙裔黑人（aOR = 6.26，95%置信区间= 2.32-16.88）和西班牙裔（aOR = 6.42，95% CI = 1.93-21.41）更可能患有持续性AD。总之，与非西班牙裔白人相比，AD的发病率和持续性在某些非白人种族/民族亚组中更高。进一步的研究是必要的，以确定环境，社会经济和遗传因素，可能是负责观察到的差异。
Although previous studies have explored racial/ethnic differences in incident atopic dermatitis (AD) in childhood, few studies have examined risk factors associated with AD persistence. As such, we sought to examine differences in incidence and persistence of childhood AD by race/ethnicity accounting for sociodemographic characteristics and perinatal vitamin D levels. Using data from Project Viva, a prospective prebirth cohort in eastern Massachusetts, we studied 1,437 mother-child pairs with known AD status to examine the associations of race/ethnicity with maternally reported child AD. We used multivariable logistic regression, adjusting for socio-demographic factors and maternal plasma vitamin D, to estimate adjusted odds ratios (aORs) of AD incidence at early childhood and persistence at mid-childhood. Compared to non-Hispanic whites, non-Hispanic blacks (aOR = 2.71, 95% confidence interval = 1.75-4.19) and other non-Hispanics (aOR = 1.80, 95% confidence interval = 1.16-2.80) were more likely to have incident AD. Non-Hispanic blacks (aOR = 6.26, 95% confidence interval = 2.32-16.88) and Hispanics (aOR = 6.42, 95% CI = 1.93-21.41) with early childhood AD were more likely to have persistent AD. In conclusion, compared with non-Hispanic whites, AD incidence and persistence are higher among certain nonwhite racial/ethnic subgroups. Further research is warranted to identify environmental, socioeconomic, and genetic factors that may be responsible for the observed differences.