Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi.
Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi.
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DOI：
10.1016/b978-0-12-404634-4.00015-2
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发表时间：
2012
影响因子：
--
通讯作者：
Keller, Nancy P.
中科院分区：
文献类型：
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作者：
Lim, Fang Yun;Sanchez, James F.;Wang, Clay C. C.;Keller, Nancy P.
由于对新药的持续需求，开采新的天然化合物具有突出的重要性。丝状真菌在历史上被认为具有天然化合物的遗传能力，对人类有益和有害。在标准实验室培养条件下，这些代谢物中的大多数仍然是隐蔽的或沉默的。挖掘这些神秘的天然产物可以成为识别新化合物类别的绝佳来源。利用目前关于次级代谢物基因簇如何调控的知识，使研究界能够解开许多隐藏的真菌宝藏，如本章所述。
Mining for novel natural compounds is of eminent importance owing to the continuous need for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic capacity for an arsenal of natural compounds, both beneficial and detrimental to humans. The majority of these metabolites are still cryptic or silent under standard laboratory culture conditions. Mining for these cryptic natural products can be an excellent source for identifying new compound classes. Capitalizing on the current knowledge on how secondary metabolite gene clusters are regulated has allowed the research community to unlock many hidden fungal treasures, as described in this chapter.