Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope
Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope
复制标题
使用原子力显微镜检测受衰老和 2 型糖尿病影响的红细胞
DOI：
10.1016/j.bbrc.2009.12.133
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发表时间：
2010-01-22
影响因子：
3.1
通讯作者：
Cai, Jiye
中科院分区：
文献类型：
--
作者：
Jin, Hua;Xing, Xiaobo;Cai, Jiye
从分子水平上检测红细胞的病理生理变化，对于揭示疾病的发生具有重要意义。2型糖尿病是一种与年龄相关的代谢紊乱，在老年人中发病率很高。到目前为止，还没有治愈糖尿病的治疗方法。因此，早期发现和监测2型糖尿病的进展对于开发有效的治疗方法是非常重要的。在胰岛素抵抗和相对胰岛素缺乏的背景下，2型糖尿病与高血糖有关。这些异常可能从分子水平上干扰红细胞的结构和功能。在这项研究中，利用原子力显微镜(AFM)在纳米尺度上清楚地表征了衰老和糖尿病引起的红细胞形态和生物力学特性的变化。红细胞表面膜的结构信息和力学性能是确定健康、疾病或衰老状态的重要指标。因此，原子力显微镜有可能发展成为诊断疾病的有力工具。(C)2010年，由爱思唯尔公司出版。
The pathophysiological changes of erythrocytes are detected at the molecular scale, which is important to reveal the onset of diseases. Type 2 diabetes is an age-related metabolic disorder with high prevalence in elderly (or old) people. Up to now, there are no treatments to cure diabetes. Therefore, early detection and the ability to monitor the progression of type 2 diabetes are very important for developing effective therapies. Type 2 diabetes is associated with high blood glucose in the context of insulin resistance and relative insulin deficiency. These abnormalities may disturb the architecture and functions of erythrocytes at molecular scale. In this study, the aging- and diabetes-induced changes in morphological and bio-mechanical properties of erythrocytes are clearly characterized at nanometer scale using atomic force microscope (AFM). The structural information and mechanical properties of the cell surface membranes of erythrocytes are very important indicators for determining the healthy, diseased or aging status. So, AFM may potentially be developed into a powerful tool in diagnosing diseases. (C) 2010 Published by Elsevier Inc.