Role of monocytes and macrophages in regulating immune response following lung transplantation.
Role of monocytes and macrophages in regulating immune response following lung transplantation.
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DOI：
10.1097/mot.0000000000000313
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发表时间：
2016-06
影响因子：
2.2
通讯作者：
Bharat A
中科院分区：
文献类型：
--
作者：
Chiu S;Bharat A
单核细胞和巨噬细胞生物学领域的进展极大地改变了我们对它们在体内平衡和炎症过程中所起作用的理解。在这里，我们回顾了这些重要的先天免疫效应器在包括肺移植在内的炎性挑战中在肺中的作用。中性粒细胞渗入肺组织和肺泡间隙已被证明是急性肺损伤和肺移植后原发移植物功能障碍的致病因素。肺免疫学的最新进展表明，单核细胞和巨噬细胞都具有显着的可塑性，并且在炎症过程中作为中性粒细胞募集和跨内皮细胞迁移的介质具有重要意义。单核细胞和巨噬细胞正在成为介导病原体反应和无菌肺炎症的关键因素，包括气压创伤和缺血再灌注损伤引起的炎症。正在进行的研究将确定这些单核细胞和巨噬细胞启动各种免疫反应的机制，为肺损伤反应奠定基本基础。
Advances in the field of monocyte and macrophage biology have dramatically changed our understanding of their role during homeostasis and inflammation. Here we review the role of these important innate immune effectors in the lung during inflammatory challenges including lung transplantation. Neutrophil extravasation into lung tissue and the alveolar space have been shown to be pathogenic during acute lung injury as well as primary graft dysfunction following lung transplantation. Recent advances in lung immunology have demonstrated the remarkable plasticity of both monocytes and macrophages and demonstrated their importance as mediators of neutrophil recruitment and transendothelial migration during inflammation. Monocytes and macrophages are emerging as key players in mediating both the pathogen response and sterile lung inflammation, including that arising from barotrauma and ischemia-reperfusion injury. Ongoing studies will establish the mechanisms by which these monocytes and macrophages initiate a variety of immune response that lay the fundamental basis of injury response in the lung.