Tumor suppressor activity of CBX7 in lung carcinogenesis
Tumor suppressor activity of CBX7 in lung carcinogenesis
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DOI：
10.4161/cc.20022
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发表时间：
2012-05-15
期刊：
影响因子：
4.3
通讯作者：
Fusco, Alfredo
中科院分区：
文献类型：
--
作者：
Forzati, Floriana;Federico, Antonella;Fusco, Alfredo
Cbx 7基因敲除小鼠的产生验证了CBX 7的肿瘤抑制作用，CBX 7的表达在几种人类恶性肿瘤中丢失。事实上，这些小鼠发生了肝和肺腺瘤和癌。由于缺乏Cbx 7对其表达的负调控而导致的细胞周期蛋白E过表达可能解释了Cbx 7-KO小鼠的表型。类似的机制可能涉及人类肺癌发生，因为在所分析的大多数人类肺癌中观察到与CBX 7表达丧失相关的细胞周期蛋白E上调。
The generation of knockout mice for the Cbx7 gene validates the tumor suppressor role of CBX7, whose expression is lost in several human malignancies. Indeed, these mice developed liver and lung adenomas and carcinomas. Cyclin E overexpression due to the lack of Cbx7-negative regulation of its expression likely accounts for the phenotype of the Cbx7-KO mice. A similar mechanism is likely involved in human lung carcinogenesis, since Cyclin E upregulation associated with the loss of CBX7 expression has been observed in most of the human lung carcinomas analyzed.