Natural History of Retinopathy of Prematurity in Infants Born Before 27 Weeks' Gestation in Sweden
Natural History of Retinopathy of Prematurity in Infants Born Before 27 Weeks' Gestation in Sweden
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DOI：
10.1001/archophthalmol.2010.234
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发表时间：
2010-10-01
影响因子：
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通讯作者：
Holmstrom, Gerd E.
中科院分区：
文献类型：
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作者：
Austeng, Dordi;Kallen, Karin B. M.;Holmstrom, Gerd E.
目的：调查早产儿视网膜病变（ROP）的自然史，在506个极端早产儿出生前27周的妊娠在Sweden.Methods：一个全国性的人口为基础的研究，在瑞典从2004年4月1日，2007年3月31日。根据研究方案，在出生后第5周进行初始眼部检查，重复检查直至视网膜完全血管化或直至符合治疗标准。每周进行一次检查，以便研究ROP的病程和严重程度。在没有ROP或轻度ROP没有进展的婴儿在最近的检查，进一步的检查进行每周或每隔一周从月经后年龄35 weeks.Results：在这项研究中，368名婴儿（72.7%）发展ROP。ROP发病时的月经后年龄与ROP的严重程度显著相关，即使在控制胎龄的情况下也是如此（即，ROP发病越早，发生严重ROP的风险越高）。ROP的发病部位与出生时的胎龄显著相关。出生时胎龄每减少一周，鼻部发病的风险几乎增加一倍。鼻发病与严重的ROP，即使调整胎龄在birth.Conclusion：这项基于人群的研究证实了结果的冷冻治疗视网膜病变的早产儿研究，并显示了新的相关性的时间和部位的ROP，这两者都与疾病的严重程度。
Objective: To investigate the natural history of retinopathy of prematurity (ROP) in 506 extremely preterm infants born before 27 weeks' gestation in Sweden during a 3-year period.Methods:A national population-based study was performed in Sweden from April 1, 2004, to March 31, 2007. According to the study protocol, initial eye examinations were to be performed at postnatal week 5, and examinations were repeated until the retina was completely vascularized or until criteria for treatment were met. The examinations were to be performed weekly, enabling study of the course and severity of ROP. In infants without ROP or with mild ROP without progression during the latest examinations, further examinations were performed weekly or every other week from postmenstrual age 35 weeks.Results: During the study, 368 infants (72.7%) developed ROP. Postmenstrual age at onset of ROP was significantly related to severity of ROP, even when controlling for gestational age (ie, the earlier the onset of ROP, the higher the risk of developing severe ROP). Site of onset of ROP was significantly related to gestational age at birth. The risk of nasal onset was almost doubled for every week of decrease in gestational age at birth. Nasal onset was associated with severe ROP, even after adjusting for gestational age at birth.Conclusion: This population-based study confirms results of the Cryotherapy for Retinopathy of Prematurity study and shows new correlations regarding time and site of onset of ROP, both of which are associated with disease severity.