Expression of granulocyte colony-stimulating factor and its receptor in epithelial skin tumors
Expression of granulocyte colony-stimulating factor and its receptor in epithelial skin tumors
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DOI：
10.1016/s0923-1811(00)00131-6
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发表时间：
2001-04-01
影响因子：
4.6
通讯作者：
Fukuda, M
中科院分区：
文献类型：
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作者：
Hirai, K;Kumakiri, M;Fukuda, M
粒细胞集落刺激因子受体（G-CSFR）不仅存在于造血细胞表面，也存在于多种癌细胞表面。在本研究中，我们研究了G-CSFR或G-CSF的表达在上皮性皮肤肿瘤免疫组化染色。通过G-CSFR或G-CSF阳性细胞的百分比定义评估，并表示为G-CSFR和G-CSF评分。SCC的G-CSFR评分（77.6 ± 20.0%）显著高于Bowen病（BD）（51.0 ± 35.6%）、光化性角化病（AK）（49.3 ± 34.6%）或正常皮肤（30.0 ± 32.1%）（分别为P = 0.0004、P = 0.0003、P < 0.0001）。SCC（56.7 ± 27.4%）和艾德（44.1 ± 31.4%）的平均G-CSF评分高于正常皮肤（24.9 ± 25.8%）（分别为P = 0.0075和P < 0.001）。AK组G-CSF表达（29.8 ± 31.2%）低于SCC组（P = 0.0037）。皮肤肿瘤G-CSFR评分与G-CSF评分呈显著正相关（γ = 0.274，P = 0.0107）。这些结果表明，G-CSFR表达的评估可能与皮肤肿瘤的癌变。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Granulocyte colony-stimulating factor receptors (G-CSFR) have been observed on the surface of not only hematopoietic cells but also several cancer cells. In the present study, we investigated the expression of G-CSFR or G-CSF in epithelial skin tumors by immunohistochemical staining. The assessments were defined by the percentage of G-CSFR or G-CSF positive cells and expressed as G-CSFR and G-CSF scores. The G-CSFR score in SCC (77.6 +/- 20.0%) was significantly higher than that in Bowen's disease (BD) (51.0 +/- 35.6%), actinic keratosis (AK) (49.3 +/- 34.6%) or normal skin (30.0 +/- 32.1%) (P = 0.0004, P = 0.0003, P < 0.0001, respectively). The mean G-CSF score in SCC (56.7 +/- 27.4%) or in ED (44.1 +/- 31.4%) was higher than that in normal skin (24.9 +/- 25.8%) (P = 0.0075, P < 0.001, respectively). G-CSF expression in AK (29.8 +/- 31.2%) was lower than that in SCC (P = 0.0037). There was significant positive correlation between the G-CSFR score and the G-CSF score (gamma = 0.274, P = 0.0107) in skin tumors. These findings suggested that the assessment of G-CSFR expression might be associated with carcinogenesis of skin tumors. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.