Immunoendocrine Findings in Patients with Eating Disorders
Immunoendocrine Findings in Patients with Eating Disorders
复制标题
饮食失调患者的免疫内分泌发现
作者：
P. Monteleone;Michael Maes;M. Fabrazzo;A. Tortorella;A. Lin;E. Bosmans;G. Kenis;M. Maj
神经性厌食症（AN）或神经性贪食症（BN）患者可能会发生免疫变化，促炎细胞因子在这两种疾病的发病机制中起作用。我们检测了21例肥胖妇女、21例暴食症妇女和21例健康女性的血浆白细胞介素（IL）-1β、IL-6、肿瘤坏死因子-α（TNF-α）、可溶性细胞因子受体蛋白gp 130和白血病抑制因子受体（LIF-R）、抗炎性Clara细胞16-kD蛋白（CC 16）、催乳素（PRL）、皮质醇和17β-雌二醇水平。与健康受试者相比，厌食症患者的gp 130和LIF-R血浆水平显著升高，而暴食症患者的CC 16血药浓度显著降低。其余免疫参数的血液水平无显著差异。两个患者组均表现出较高的血浆皮质醇水平和降低的血浆PRL和17β-雌二醇浓度。在低氧血症患者中，血浆gp 130或LIF-R水平与体重指数呈显著负相关。这些发现不支持这一假设，即促炎细胞因子可能发挥致病作用的饮食失调。
Immune changes may occur in patients with anorexia nervosa (AN) or bulimia nervosa (BN), and a role for proinflammatory cytokines has been proposed in the pathogenesis of both disorders. We measured plasma levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), soluble forms of the cytokine receptor proteins gp130 and leukemia inhibitory factor receptor (LIF-R), the anti-inflammatory Clara cell 16-kD protein (CC16), prolactin (PRL), cortisol and 17β-estradiol in 21 anorexic women, 21 bulimic women and 21 healthy females. As compared to healthy subjects, anorexics exhibited significantly increased plasma levels of gp130 and LIF-R, whereas bulimics had significantly decreased blood concentrations of CC16. No significant differences emerged in the blood levels of the remaining immune parameters. Both patient groups manifested higher plasma levels of cortisol and reduced plasma concentrations of PRL and 17β-estradiol. In anorexics, a significant negative correlation was found between plasma levels of gp130 or LIF-R and the body mass index. These findings do not support the hypothesis that proinflammatory cytokines may play a pathogenetic role in eating disorders.
神经性贪食症中血清素功能降低。
影响因子：
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作者：
Jimerson,DC;Wolfe,BE;Metzger,ED;Finkelstein,DM;Cooper,TB;Levine,JM
通讯作者：
Levine,JM