VEGF and Notch in Tip and Stalk Cell Selection
VEGF and Notch in Tip and Stalk Cell Selection
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DOI：
10.1101/cshperspect.a006569
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发表时间：
2013-01-01
影响因子：
5.4
通讯作者：
Gerhardt, Holger
中科院分区：
文献类型：
--
作者：
Blanco, Raquel;Gerhardt, Holger
萌芽血管生成是一个动态过程，其中内皮细胞集体迁移，形成新的管腔化管，建立新的连接，并将新生网络重塑为分层分支和功能灌注的血管床。新生芽中的内皮细胞采用两种不同的细胞表型称为尖细胞和柄细胞具有特殊的功能和基因表达模式。VEGF和Notch信号传导参与复杂的串扰以平衡尖端和柄细胞形成并调节定向尖端细胞迁移和柄细胞增殖。在这篇文章中，我们总结了目前的知识和影响的尖端/柄细胞的概念和定量和动态整合的VEGF和Notch信号在尖端和柄细胞的选择。
Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate, shape new lumenized tubes, make new connections, and remodel the nascent network into a hierarchically branched and functionally perfused vascular bed. Endothelial cells in the nascent sprout adopt two distinct cellular phenotypes-known as tip and stalk cells-with specialized functions and gene expression patterns. VEGF and Notch signaling engage in an intricate cross talk to balance tip and stalk cell formation and to regulate directed tip cell migration and stalk cell proliferation. In this article, we summarize the current knowledge and implications of the tip/stalk cell concepts and the quantitative and dynamic integration of VEGF and Notch signaling in tip and stalk cell selection.