Population-Based Study of ABCD2 Score, Carotid Stenosis, and Atrial Fibrillation for Early Stroke Prediction After Transient Ischemic Attack The North Dublin TIA Study
Population-Based Study of ABCD2 Score, Carotid Stenosis, and Atrial Fibrillation for Early Stroke Prediction After Transient Ischemic Attack The North Dublin TIA Study
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DOI：
10.1161/strokeaha.109.571844
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发表时间：
2010-05-01
期刊：
影响因子：
8.3
通讯作者：
Kelly, Peter J.
中科院分区：
文献类型：
--
作者：
Sheehan, Orla C.;Kyne, Lorraine;Kelly, Peter J.
背景和目的：短暂性脑缺血发作（TIA）的病因学数据和ABCD（2）评分可能改善早期卒中风险预测，但需要在人群队列中进行研究。我们调查了ABCD（2）评分、颈动脉狭窄和房颤预测TIA后早期复发性卒中的外部效度。方法：通过重叠医院和社区来源，确定北都柏林城市人群（N=294 529）中TIA患者。结果在确诊的TIA病例中（n=443），颈动脉狭窄预测90天卒中（危险比=2.56; 95% CI，1.27 ~ 5.15，P=0.003）。卒中风险随着颈动脉狭窄程度的增加而增加，范围为5.4%（95%CI，3.3%至8.7%），
Background and Purpose-Transient ischemic attack (TIA) etiologic data and the ABCD(2) score may improve early stroke risk prediction, but studies are required in population-based cohorts. We investigated the external validity of the ABCD(2) score, carotid stenosis, and atrial fibrillation for prediction of early recurrent stroke after TIA.Methods-Patients with TIA in the North Dublin city population (N=294 529) were ascertained by using overlapping hospital and community sources. The relations between individual ABCD(2) items, carotid stenosis, atrial fibrillation, and early stroke were examined.Results-In confirmed TIA cases (n=443), carotid stenosis predicted 90-day stroke (hazard ratio=2.56; 95% CI, 1.27 to 5.15, P=0.003). Stroke risk rose with increasing grade of carotid stenosis, ranging from 5.4% (95% CI, 3.3% to 8.7%) with