Development of an Aggressive Depressed Cancer in a Case of Familial Adenomatous Polyposis
Development of an Aggressive Depressed Cancer in a Case of Familial Adenomatous Polyposis
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家族性腺瘤性息肉病病例中侵袭性抑郁性癌症的发展
DOI：
10.1055/s-2002-25288
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发表时间：
2002
期刊：
影响因子：
9.3
通讯作者：
Yasushi Sano
中科院分区：
文献类型：
--
作者：
Yutaka Saito;Takahiro Fujii;Takayuki Akasu;Takuji Gotoda;T. Kozu;Daizo Saito;Yasushi Sano
1977 年，刈谷等人。报道了一例家族性腺瘤性息肉病 (FAP) 患者患有小型凹陷性癌症的病例，这提出了并非 FAP 中的所有癌症都是由息肉样腺瘤发展而来的可能性。现在人们广泛认识到结肠腺瘤可能表现为平坦或凹陷的病变。然而，家族性腺瘤性息肉病 (FAP) 患者中发生的结直肠癌仍被认为是按照息肉癌序列从腺瘤性息肉演变而来。我们报道了一名 FAP 患者的病例，该患者在结肠次全切除和回直肠吻合术 23 年后发展为直肠癌。我们认为，由于病变的凹陷形状和侵袭性生长模式，这种恶性肿瘤可能是从头发生的。该病例提出了一种可能性，即 FAP 中的癌并不总是由息肉演变而来。在检查 FAP 患者的直肠残端时，应寻找外观凹陷的侵袭性癌症。
In 1977, Kariya et al. reported a case of a small depressed cancer in a patient with familial adenomatous polyposis (FAP) raising the possibility that not all cancers in FAP develop from polypoid adenomas. It is now becoming widely recognized that colonic adenomas may appear as flat or depressed lesions. However, colorectal cancers developing in patients with familial adenomatous polyposis (FAP) are still thought to evolve from adenomatous polyps following the polyp-carcinoma sequence. We report the case of a patient with FAP in whom rectal carcinoma developed 23 years after subtotal colectomy and ileorectal anastomosis. We suggest that this malignancy may have developed de novo because of the depressed shape of the lesion and the aggressive growth pattern. This case raises the possibility that carcinomas may not always evolve from polyps in FAP. Aggressive cancers with a depressed appearance should be searched for when surveying the rectal stump in patients with FAP.
影响因子：
158.5
作者：
VOGELSTEIN, B;FEARON, ER;BOS, JL
通讯作者：
BOS, JL