Effect of a High-Protein Diet versus Standard-Protein Diet on Weight Loss and Biomarkers of Metabolic Syndrome: A Randomized Clinical Trial
Effect of a High-Protein Diet versus Standard-Protein Diet on Weight Loss and Biomarkers of Metabolic Syndrome: A Randomized Clinical Trial
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DOI：
10.1159/000471485
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发表时间：
2017-06-01
期刊：
影响因子：
3.6
通讯作者：
Barquera, Simon
中科院分区：
文献类型：
--
作者：
Campos-Nonato, Ismael;Hernandez, Lucia;Barquera, Simon
背景：一些研究表明，与标准蛋白质饮食相比，富含蛋白质的饮食可以带来更大的体重减轻和代谢综合征（MeS）生物标志物的改善。因此，本研究的目的是确定增加蛋白质摄入量对患有 MeS 的墨西哥成年人体重减轻的影响。方法：对 118 名年龄 47.4 +/- 11.5 岁且符合 MeS 既定标准的成年人进行随机对照试验，随机接受规定的低热量饮食（比静息代谢率低 500 kcal），提供 0.8 g/kg 体重（标准蛋白质饮食 (SPD)）或 1.34 g/kg 体重（高蛋白质饮食 (HPD)），为期 6 个月。体重、腰围、生物阻抗分析体脂百分比、空腹血糖、空腹胰岛素、血红蛋白 A1c、总胆固醇、高密度脂蛋白 (HDL) 胆固醇、极低密度脂蛋白 (VLDL) 胆固醇、甘油三酯、C 反应蛋白、肌酐、血尿素氮、丙氨酸 在基线、3个月和6个月时测量转氨酶、天冬氨酸转氨酶和γ-谷氨酰转移酶。结果：共有 105 名受试者（51 名 SPD 和 54 名 HPD）完成了试验。 SPD 组的总体体重减轻了 5.1 +/- 3.6 公斤，而 HPD 组的总体体重减轻了 7.0 +/- 3.7 公斤。两组的腰围均显着减少了百分之几厘米（SPD -6.5 +/- 2.6 cm 和 HPD -8.8 +/- 2.6 cm）。没有统计学差异 除了不同的体重减轻之外，两组总体上没有显示出任何进一步的差异。然而，在被认为在超过 75% 的时间内坚持规定饮食的亚组中，调整基线 BMI 后，平均体重减轻存在显着差异（SPD -5.8% 与 HPD -9.5%）。两组的腰围、血糖、胰岛素、甘油三酯和极低密度脂蛋白胆固醇均显着下降，但两组之间没有差异。肝或肾功能的血液检查没有变化。结论：对整个组进行检查时，体重减轻和 MeS 生物标志物没有显着差异，但 HPD 组中依从率较高的参与者比 SPD 组中依从率较高的参与者减轻的体重明显更多。 (C) 2017 作者由弗莱堡 S. Karger GmbH 出版
Background: Some studies have shown that protein-enriched diets can lead to greater weight loss and improvements in biomarkers of metabolic syndrome (MeS) than standard protein diets. Therefore, the aim of this study was to determine the effect of increased protein intake on weight loss in Mexican adults with MeS. Methods: Randomized controlled trial in 118 adults aged 47.4 +/- 11.5 years and meeting the established criteria for MeS were randomized to prescribed hypocaloric diets (500 kcal less than resting metabolic rate) providing either 0.8 g/kg body weight (standard protein diet (SPD)) or 1.34 g/kg body weight (higher protein diet (HPD)) for 6 months. Body weight, waist circumference, percent body fat by bioimpedance analysis, fasting blood glucose, fasting insulin, hemoglobin A1c, total cholesterol, high-density lipoprotein (HDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, triglycerides, C-reactive protein, creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase were measured at baseline, 3 months and at 6 months. Results: There were 105 subjects (51 for SPD and 54 for HPD) who completed the trial. Overall weight loss was 5.1 +/- 3.6 kg in the SPD group compared to 7.0 +/- 3.7 kg in the in HPD group. Both groups lost a significant percent of centimeters of waist circumference (SPD -6.5 +/- 2.6 cm and HPD -8.8 +/- 2.6 cm). There was no statistical difference Except for the varying weight losses the two groups did not show any further differences overall. However in the subgroup judged to be adherent more than 75% of the time with the prescribed diets, there was a significant difference in mean weight loss (SPD -5.8% vs. HPD -9.5%) after adjusting for baseline BMI. Both groups demonstrated significant decreases in waist circumference, glucose, insulin, triglycerides, and VLDL cholesterol, but there were no differences between the groups. There were no changes in blood tests for liver or renal function. Conclusions: There were no significant differences in weight loss and biomarkers of MeS when the overall group was examined, but the participants with more adherence rate in the HPD group lost significantly more weight than adherent participants in the SPD group. (C) 2017 The Author(s) Published by S. Karger GmbH, Freiburg