Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer.
Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer.
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阶段特异性胚胎抗原4是反映前列腺癌恶性行为的组织学标志物。
DOI：
10.1007/s10719-019-09882-2
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Sakai H.
中科院分区：
文献类型：
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作者：
Nakamura Y;Miyata Y;Matsuo T;Shida Y;Hakariya T;Ohba K;Taima T;Ito A;Suda T;Hakomori SI;Saito S;Sakai H.
阶段特异性胚胎抗原-4（SSEA-4）是多能干细胞的特异性标志物，在多种癌症的恶性行为中起重要作用。在这里，SSEA-4的表达进行了评估，通过免疫组织化学使用单克隆抗体RM 1特异性SSEA-4在181和117前列腺癌（PC）标本获得活检和根治性前列腺切除术（RP），分别。分析癌细胞中SSEA-4表达或SSEA-4阳性肿瘤浸润免疫细胞（TIC）的存在与临床病理参数之间的关系。SSEA-4在癌细胞中的表达与Gleason评分、局部进展、淋巴结转移和远处转移显著相关。在RP样本中，癌细胞中的高SSEA-4表达和SSEA-4阳性TIC的存在是pT 3的显著预测因子，即，单因素分析显示，RP后的侵袭性和更差生化复发（BCR）。相反，在多变量分析中，癌细胞中SSEA-4高表达和SSEA-4阳性TIC的存在的组合是pT 3和BCR的独立预测因子。在生物学上，这种组合也与细胞凋亡的抑制独立相关。因此，SSEA-4在癌细胞和TIC中的共表达可能在PC的恶性侵袭性和预后中具有关键作用。侵袭潜力和细胞凋亡的抑制可能与SSEA-4表达有关。
Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3,i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression.