Association between Genetic Variants of Transforming Growth Factor-β1 and Susceptibility of Pneumoconiosis: A Meta-analysis.
Association between Genetic Variants of Transforming Growth Factor-β1 and Susceptibility of Pneumoconiosis: A Meta-analysis.
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DOI：
10.4103/0366-6999.198917
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发表时间：
2017-02-05
影响因子：
6.1
通讯作者：
Bai C
中科院分区：
文献类型：
--
作者：
Deng CW;Zhang XX;Lin JH;Huang LF;Qu YL;Bai C
转化生长因子-β1 (TGF-β1) 和基因变异体在各种人类疾病中已得到广泛研究。例如，TGF-β1 多态性与纤维化和尘肺病相关，但数据仍存在争议。本荟萃分析的目的是评估 TGF-β1 -509 C>T [rs1800469]、+869 T>C [rs1800470] 和 +915 G>C [rs1800471] 多态性与尘肺病之间的关联。截至2016年4月，通过检索PubMed、Embase、中国生物医学数据库和韦普数据库进行了全面的文献检索。本次荟萃分析纳入了11篇出版物、21项研究，共覆盖4333名尘肺病患者和3478名对照者。评估研究质量，并测量异质性和发表偏倚。所有统计分析均使用 STATA 12.0 版（StataCorp，College Station，TX，USA）软件进行。数据显示TGF-β1 -509 C>T多态性与尘肺发展风险之间存在显着相关性（T vs. C，比值比[OR] = 1.35，95%置信区间[CI]：1.00–1.81，P = 0.046）； TGF-β1 +915 G>C 多态性与尘肺病风险之间的比较（C vs. G，OR = 1.69，95% CI：1.19–2.40，P = 0.004；CG vs. GG，OR = 1.79，95% CI：1.23–2.60，P = 0.002；CC+CG vs. GG，OR = 1.80，95% CI：1.24–2.61，P = 0.002）。此外，种族与尘肺病类型的亚组分析表明，亚洲人群中的矽肺病存在显着相关性，但白人人群中的煤工尘肺病则没有显着相关性。相反，TGF-β1 +869 T>C 多态性与尘肺病风险之间没有显示出显着相关性。 TGF-β1 -509 C>T 和 +915 G>C 多态性均与尘肺病风险增加相关。
Transforming growth factor-beta 1 (TGF-β1) and gene variants have been extensively studied in various human diseases. For example, TGF-β1 polymorphisms were associated with fibrosis and pneumoconiosis, but the data remained controversial. The aim of this meta-analysis was to assess the association between TGF-β1 −509 C>T [rs1800469], +869 T>C [rs1800470], and +915 G>C [rs1800471] polymorphisms and pneumoconiosis. A comprehensive literature search was conducted through searching in PubMed, Embase, the Chinese Biomedical Database, and the Wei Pu (Chinese) Database by the end of April 2016. Eleven publications with 21 studies were included in this meta-analysis, covering a total of 4333 patients with pneumoconiosis and 3478 controls. Study quality was assessed, and heterogeneity and publication bias were measured. All statistical analyses were performed using STATA version 12.0 (StataCorp, College Station, TX, USA) software. The data showed significant associations between TGF-β1 −509 C>T polymorphism and the risk of pneumoconiosis development (T vs. C, odds ratio [OR] = 1.35, 95% confidence interval [CI]: 1.00–1.81, P = 0.046); between TGF-β1 +915 G>C polymorphism and the pneumoconiosis risk (C vs. G, OR = 1.69, 95% CI: 1.19–2.40, P = 0.004; CG vs. GG, OR = 1.79, 95% CI: 1.23–2.60, P = 0.002; CC+CG vs. GG, OR = 1.80, 95% CI: 1.24–2.61, P = 0.002). In addition, the subgroup analysis of ethnicity versus pneumoconiosis types indicated a significant association of silicosis among Asian populations but not that of coal workers’ pneumoconiosis in Caucasian populations. In contrast, no significant association was exhibited between TGF-β1 +869 T>C polymorphism and risk of pneumoconiosis. The polymorphisms of both TGF-β1 −509 C>T and +915 G>C are associated with increased risk of pneumoconiosis.