The influence of smoking and HIV infection on pulmonary function.
The influence of smoking and HIV infection on pulmonary function.
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DOI：
10.4102/sajhivmed.v23i1.1329
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发表时间：
2022
影响因子：
1.7
通讯作者：
Vos AG
中科院分区：
文献类型：
--
作者：
Sussenbach AE;van Gijzel SWL;Lalla-Edward ST;Venter WDF;Shaddock E;Feldman C;Klipstein-Grobusch K;Vos AG
南非艾滋病毒、吸烟和肺部感染的流行率很高。我们研究了吸烟和HIV状态对肺功能的作用。这是对在南非进行的一项横断面研究的二次分析。资料包括人口统计学、肺危险因素和肺功能测定法，以获得一秒钟用力呼气量（FEV 1）和FEV 1/用力肺活量（FVC）的比值。在最初的多变量回归分析中，评估了吸烟对HIV阳性成人肺功能的影响。重复分析，评估HIV状态对HIV阴性和HIV阳性吸烟者肺功能的影响。这些模型根据年龄，性别，体重指数（BMI），自艾滋病毒诊断以来的时间，抗逆转录病毒治疗（ART）的使用，职业危害，结核病或肺炎史，室内吸烟和儿童时期室内壁炉的存在进行了调整。这项研究包括524名艾滋病毒感染者（PLWH，66.7%女性，平均年龄40.9岁[s.d.; 9.4]）和79例HIV阴性吸烟者（77.2%男性，平均年龄34.4岁[s.d.：12.1]）。在PLWH中，118人（22.5%）是过去或现在的吸烟者，406人（77.5%）是非吸烟者。在多变量回归分析中，吸烟与FEV 1或FEV 1/FVC比值的变化无关。在第二项分析中，调整混杂因素后，HIV状态也与肺功能降低无关。在这个相对年轻的人群中，吸烟和HIV阳性都与肺功能下降无关。这些发现应在纵向研究中得到证实，包括老年人口。
Prevalence of HIV, smoking, and pulmonary infections in South Africa are high. We investigated the role of smoking and HIV status on lung function. This is a secondary analysis of a cross-sectional study conducted in South Africa. Data included demographics, pulmonary risk factors and a spirometry test to obtain the forced expiratory volume in one second (FEV1) and the ratio of FEV1/forced vital capacity (FVC). In the initial multivariable regression analysis, the effect of smoking on pulmonary function in HIV-positive adults was assessed. The analysis was repeated, assessing the influence of HIV status on lung function in both HIV-negative and HIV-positive smokers. The models were adjusted for age, sex, body mass index (BMI), time since HIV diagnosis, antiretroviral treatment (ART) use, occupational hazards, history of tuberculosis or pneumonia, indoor smoking and the presence of an indoor fireplace during childhood. This study included 524 people living with HIV (PLWH, 66.7% female, mean age 40.9 years [s.d.; 9.4]) and 79 HIV-negative smokers (77.2% male, mean age 34.4 years [s.d.: 12.1]). Of the PLWH, 118 (22.5%) were past or current smokers and 406 (77.5%) were non-smokers. Smoking was not associated with changes in the FEV1 or FEV1/FVC ratio in multivariable regression analysis. In the second analysis, HIV status was also not associated with reduced pulmonary function following adjustment for confounders. Neither smoking nor being HIV-positive was associated with decreased pulmonary function in this relatively young population. These findings should be confirmed in a longitudinal study, including an older population.
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