Preparation of 2-arylpropanoic acids by oxidative aryl migration in (β-aryl-β-hydroxy)alkyl phenyl selenides
Preparation of 2-arylpropanoic acids by oxidative aryl migration in (β-aryl-β-hydroxy)alkyl phenyl selenides
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DOI：
10.1039/p19900000907
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
S. Uemura;K. Ohe;T. Yamauchi;S. Mizutaki;K. Tamaki
中科院分区：
文献类型：
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作者：
S. Uemura;K. Ohe;T. Yamauchi;S. Mizutaki;K. Tamaki
Oxidation of diastereoisomeric mixtures of 1-aryl-1-hydroxyprop-2-yl phenyl selenides, prepared either by phenylselenenylation of propiophenones followed by reduction or by treatment of benzaldehyde with α-(phenylseleno)ethyl anion, with an excess of meta-chloroperbenzoic acid in methanol at 25 °C for 24 h or at reflux for 2 h affords methyl 2-arylpropanoates almost quantitatively. Similar treatment in tetrahydrofuran at 25 °C for 24 h results in a direct formation of 2-arylpropanoic acids in high yields.
