Defining the computational structure of the motion detector in Drosophila.
Defining the computational structure of the motion detector in Drosophila.
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DOI:
10.1016/j.neuron.2011.05.023
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发表时间:
2011-06-23
期刊:
影响因子:
16.2
通讯作者:
Clandinin TR
中科院分区:
文献类型:
--
作者:
Clark DA;Bursztyn L;Horowitz MA;Schnitzer MJ;Clandinin TR
Many animals rely on visual motion detection for survival. Motion information is extracted from spatiotemporal intensity patterns on the retina, a paradigmatic neural computation. A phenomenological model, the Hassenstein-Reichardt Correlator (HRC), relates visual inputs to neural and behavioral responses to motion, but the circuits that implement this computation remain unknown. Using cell-type specific genetic silencing, minimal motion stimuli, and in vivo calcium imaging, we examine two critical HRC inputs. These two pathways respond preferentially to light and dark moving edges. We demonstrate that these pathways perform overlapping but complementary subsets of the computations underlying the HRC. A numerical model implementing differential weighting of these operations displays the observed edge preferences. Intriguingly, these pathways are distinguished by their sensitivities to a stimulus correlation that corresponds to an illusory percept, “reverse phi”, that affects many species. Thus, this computational architecture may be widely used to achieve edge selectivity in motion detection.
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DOI:
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发表时间:
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