Defining the computational structure of the motion detector in Drosophila.

Defining the computational structure of the motion detector in Drosophila.
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DOI:
10.1016/j.neuron.2011.05.023
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发表时间:
2011-06-23
期刊:
影响因子:
16.2
通讯作者:
Clandinin TR
Clandinin TR
中科院分区:
医学1区
文献类型:
--
作者:
Clark DA;Bursztyn L;Horowitz MA;Schnitzer MJ;Clandinin TR

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许多动物依靠视觉运动检测来生存。运动信息是从视网膜上的时空强度模式中提取的,这是一种典型的神经计算。一个现象学模型,Hassenstein-Reichardt相关器(HRC),将视觉输入与运动的神经和行为反应联系起来,但实现这种计算的电路仍然未知。使用细胞类型特异性遗传沉默,最小的运动刺激,和在体内钙成像,我们检查两个关键的HRC输入。这两条通路优先响应亮和暗的移动边缘。我们证明,这些途径执行重叠,但互补的子集的计算基础的人权委员会。实施这些操作的差分加权的数值模型显示所观察到的边缘偏好。有趣的是,这些通路的区别在于它们对刺激相关性的敏感性,这种刺激相关性对应于一种影响许多物种的错觉,即“反向phi”。因此,这种计算架构可以被广泛用于实现运动检测中的边缘选择性。
Many animals rely on visual motion detection for survival. Motion information is extracted from spatiotemporal intensity patterns on the retina, a paradigmatic neural computation. A phenomenological model, the Hassenstein-Reichardt Correlator (HRC), relates visual inputs to neural and behavioral responses to motion, but the circuits that implement this computation remain unknown. Using cell-type specific genetic silencing, minimal motion stimuli, and in vivo calcium imaging, we examine two critical HRC inputs. These two pathways respond preferentially to light and dark moving edges. We demonstrate that these pathways perform overlapping but complementary subsets of the computations underlying the HRC. A numerical model implementing differential weighting of these operations displays the observed edge preferences. Intriguingly, these pathways are distinguished by their sensitivities to a stimulus correlation that corresponds to an illusory percept, “reverse phi”, that affects many species. Thus, this computational architecture may be widely used to achieve edge selectivity in motion detection.
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