Bowenoid Papulosis: Presence of Human Papillomavirus (HPV) Structural Antigens and of HPV 16-Related DNA Sequences
Bowenoid Papulosis: Presence of Human Papillomavirus (HPV) Structural Antigens and of HPV 16-Related DNA Sequences
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鲍温样丘疹病：存在人乳头瘤病毒 (HPV) 结构抗原和 HPV 16 相关 DNA 序列
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
L. Gissmann
中科院分区：
文献类型：
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作者：
G. Gross;M. Hagedorn;H. Ikenberg;T. Rufli;Catherine Dahlet;E. Grosshans;L. Gissmann
† This study reviews 39 cases of anogenital bowenoid papulosis lesions in 22 individuals of both sexes that were analyzed clinically, histologically, immunocytochemically, and virologically. Macroscopically, three different types of lesions were demonstrated: erythematous macules; papules (lichenoid and/or pigmented papules); and leukoplakialike lesions. Microscopically, bowenoid papulosis fulfills the criteria of a squamous cell carcinoma in situ. Much like oral precancers, three distinct growth patterns (flat, endophytic, and exophytic) could be differentiated, which did not correlate with the clinical aspect of the lesions. In only two (5.12%) of the 39 cases of bowenoid papulosis could structural antigens of papillomaviruses be detected immunocytochemically (peroxidase-antiperoxidase technique). The DNA from 12 lesions that were analyzed for the presence of papillomavirusspecific sequences hybridized stringently in all cases with the human papillomavirus 16 specific DNA probe labeled with phosphorus 32. ( Arch Dermatol 1985;121:858-863)
