Flattening and Unpacking Human Genetic Variation in Mexico, Postwar to Present.
Flattening and Unpacking Human Genetic Variation in Mexico, Postwar to Present.
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战后至今墨西哥的人类基因变异的扁平化和解压。
DOI：
10.1017/s0269889717000047
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发表时间：
2017
影响因子：
0.3
通讯作者：
Anaya-Muñoz VH
中科院分区：
文献类型：
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作者：
Anaya-Muñoz VH
本文分析了墨西哥人类遗传学研究中三个不同案例的研究策略——Rubén Lisker 在 1960 年代的工作、INMEGEN 2004 年至 2009 年间绘制的墨西哥基因组多样性图谱，以及 Andrés Moreno 及其同事在当代研究中对美洲原住民变异的分析。我们区分了一种将多学科资源纳入抽样设计和解释（拆包）的方法，与一种优先考虑务实考虑而不是更强大的多学科分析（扁平化）的方法。这些选择对社会、人口和生物医学实践以及人类遗传变异的解释都有影响。前一种策略揭示了细粒度的遗传变异——有利于精确性和现实性，而后者则倾向于消除个体差异和历史深度，而不是概括。
This paper analyzes the research strategies of three different cases in the study of human genetics in Mexico – the work of Rubén Lisker in the 1960s, INMEGEN's mapping of Mexican genomic diversity between 2004 and 2009, and the analysis of Native American variation by Andrés Moreno and his colleagues in contemporary research. We make a distinction between an approach that incorporates multiple disciplinary resources into sampling design and interpretation (unpacking), from one that privileges pragmatic considerations over more robust multidisciplinary analysis (flattening). These choices have consequences for social, demographic, and biomedical practices, and also for accounts of genetic variation in human populations. While the former strategy unpacks fine-grained genetic variation – favoring precision and realism, the latter tends to flatten individual differences and historical depth in lieu of generalization.