Characteristics of invasive bladder cancers: histological and molecular markers.
Characteristics of invasive bladder cancers: histological and molecular markers.
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发表时间：
1996-05
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通讯作者：
M. Liebert;J. Seigne
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文献类型：
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作者：
M. Liebert;J. Seigne
基因表达的变化允许出现具有能够侵袭和转移的生物学特性的癌细胞克隆。本文对浸润性膀胱癌的各种遗传和抗原标记物进行了综述。尽管许多这些标记物在浸润性膀胱癌中的预后和诊断作用仍有待充分评估，但这篇综述将为临床医生提供关于该领域现状的资料。细胞生物学和遗传学的改变无疑促进了浸润性膀胱癌的侵袭和转移过程，并可能为未来侵袭性膀胱癌患者的识别和治疗提供重要的有用信息。
Changes in gene expression permit the emergence of clones of cancer cells with biological properties that enable invasion and metastasis. We present in this article an overview of the variety of genetic and antigenic markers that have been reported for invasive bladder cancer. Although the prognostic and diagnostic usefulness of many of these markers in invasive bladder cancer remains to be fully evaluated, this review will serve as a resource for the clinician on the current state of the field. Alterations in the biology and genetics of cells no doubt contribute to the processes of invasion and metastasis and are likely to provide important, useful information for future identification and management of the patient with invasive bladder cancer.