α-Pyrones and Diketopiperazine Derivatives from the Marine-Derived Actinomycete Nocardiopsis dassonvillei HR10-5
α-Pyrones and Diketopiperazine Derivatives from the Marine-Derived Actinomycete Nocardiopsis dassonvillei HR10-5
复制标题
DOI：
10.1021/np200597m
复制
发表时间：
2011-10-01
影响因子：
5.1
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Fu, Peng;Liu, Peipei;Zhu, Weiming
从海洋来源的达松维氏放线菌HR10-5中分离得到三个新的α-吡喃酮类化合物：诺卡宾E-G(1-3)和三个新的二酮并哌嗪衍生物诺卡津A-C(4-6)，以及一个新的恶唑啉化合物诺卡唑啉A(7)。1-7的新结构经波谱分析、X-射线单晶衍射、圆二色谱、改进的Mosher和Marfey方法确证。化合物1-3对枯草芽孢杆菌有一定的抗菌活性，其MIC值分别为26、14和12µM。
Three new alpha-pyrones, nocapyrones E-G (1-3), and three new diketopiperazine derivatives, nocazines A-C (4-6), together with a new oxazoline compound, nocazoline A (7), were isolated from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5. The new structures of 1-7 were determined by spectroscopic analysis, X-ray single-crystal diffraction, CD spectra, and modified Mosher and Marfey methods. Compounds 1-3 showed modest antimicrobial activity against Bacillus subtilis with MIC values of 26, 14, and 12 mu M, respectively.