Functional variants in the lipoprotein lipase gene and risk cardiovascular disease.
Functional variants in the lipoprotein lipase gene and risk cardiovascular disease.
复制标题
脂蛋白脂肪酶基因的功能变异与心血管疾病的风险有关。
DOI：
--
复制
发表时间：
1999
影响因子：
4.4
通讯作者：
John E. Hokanson
中科院分区：
文献类型：
--
作者：
John E. Hokanson
目前的报告是基于已发表的以人群为基础的研究，对脂蛋白脂酶基因变异与心血管疾病之间的关系进行了定量综述。16项研究，代表17,630个个体，报告了脂蛋白脂酶基因变异在患者和对照个体中的等位基因分布。患者的结果包括临床心血管疾病事件、基于血管造影术的记录的冠状动脉疾病或B型超声检查的内膜中层增厚。Mantel-Haenszel分层分析被用来计算脂蛋白脂肪酶基因中罕见等位基因与疾病状态之间的汇总优势比和95%可信区间。由于不同脂蛋白脂肪酶变异的潜在影响不同，每个脂蛋白脂肪酶突变等位基因都被单独考虑。脂蛋白脂肪酶D9N/-93G对T等位基因的总优势比为2.03(95%可信区间为1.30-3.18)，表明携带该等位基因变异的携带者患冠状动脉疾病的风险增加了两倍。稀有脂蛋白脂肪酶G188E变异与心血管疾病关系的汇总优势比为5.25(95%可信区间1.54-24.29)。脂蛋白脂酶N291S等位基因与心血管疾病的边际增加相关(汇总优势比1.25，95%可信区间0.99-1.60，P=0.07)。然而，有更有力的证据表明，在某些人群中存在积极的关联。脂蛋白脂酶S447X等位基因的汇总优势比为0.81(95%可信区间为0.65~1.0)，表明该脂蛋白脂酶基因变异体具有心脏保护作用。因此，脂蛋白脂酶基因变异与心血管疾病的不同易感性有关。
The current report is a quantitative review of the relationship between lipoprotein lipase gene variants and cardiovascular disease based on published population-based studies. Sixteen studies, representing 17,630 individuals, report allelic distribution for lipoprotein lipase gene variants among patients and control individuals. Patient outcomes included clinical cardiovascular disease events, documented coronary disease based on angiography, or intimal media thickening by B-mode ultrasonography. Mantel-Haenszel stratified analysis was used to compute a summary odds ratio and 95% confidence intervals for the association between rare allele in the lipoprotein lipase gene and disease status. Because of potential differing effects associated with different lipoprotein lipase variants, each lipoprotein lipase mutant allele was considered separately. The lipoprotein lipase D9N/-93G to T allele has a summary odds ratio of 2.03 (95% confidence interval 1.30-3.18), indicating a twofold increase in risk of coronary disease for carriers with this allelic variant. The summary odds ratio for the relationship of the rare lipoprotein lipase G188E variant with cardiovascular disease is 5.25 (95% confidence interval 1.54-24.29). The lipoprotein lipase N291S allele is associated with a marginal increase in cardiovascular disease (summary odds ratio 1.25, 95% confidence interval 0.99-1.60, P = 0.07). However, there is stronger evidence for a positive association in certain populations. The summary odds ratio for lipoprotein lipase S447X allele is 0.81 (95% confidence interval 0.65-1.0), which indicates a cardioprotective effect of this lipoprotein lipase gene variant. Thus, lipoprotein lipase gene variants are associated with differential susceptibility to cardiovascular disease.
登录
查看更多内容
DOI：
10.1016/s0021-9258(19)39449-9
发表时间：
1990-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Mitsuru Emi;Dana E. Wilson;P. Iverius;Lily L. Wu;Aaron N. Hata;Robert A. Hegele;Roger R. Williams;J. Lalouel
通讯作者：
Mitsuru Emi;Dana E. Wilson;P. Iverius;Lily L. Wu;Aaron N. Hata;Robert A. Hegele;Roger R. Williams;J. Lalouel
家族性非胰岛素依赖型糖尿病家族高甘油三酯血症成员脂蛋白脂肪酶基因的分子筛查。
DOI：
10.1210/jcem.79.5.7962342
发表时间：
1994
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Elbein,SC;Yeager,C;Kwong,LK;Lingam,A;Inoue,I;Lalouel,JM;Wilson,DE
通讯作者：
Wilson,DE
脂蛋白脂肪酶增强低密度脂蛋白与动脉源性细胞外基质蛋白聚糖的相互作用。
影响因子：
6.5
作者：
Edwards,IJ;Goldberg,IJ;Parks,JS;Xu,H;Wagner,WD
通讯作者：
Wagner,WD
LPL 启动子 -93T/G 转变影响非裔美国人和西班牙裔的空腹和餐后血浆甘油三酯反应。
影响因子：
6.5
作者：
Talmud,PJ;Hall,S;Holleran,S;Ramakrishnan,R;Ginsberg,HN;Humphries,SE
通讯作者：
Humphries,SE
错义突变纯合先证者的扩展谱系中杂合脂蛋白脂肪酶缺陷的表型表达。
DOI：
10.1172/jci114770
发表时间：
1990
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Wilson,DE;Emi,M;Iverius,PH;Hata,A;Wu,LL;Hillas,E;Williams,RR;Lalouel,JM
通讯作者：
Lalouel,JM