Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness.
Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness.
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运动引起的醛固酮和加压素升高会导致高山病。
DOI：
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发表时间：
1991
影响因子：
3.3
通讯作者：
O. Oelz
中科院分区：
文献类型：
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作者：
P. Bärtsch;M. Maggiorini;W. Schobersberger;S. Shaw;W. Rascher;J. Girard;P. Weidmann;O. Oelz
研究人员对 17 名登山者进行了研究，他们在自行车测力计上进行了 30 分钟的运动测试，在低海拔 (LA) 时进行了 148 +/- 9 (SE) W 的恒定工作负荷，在到达 4,559 m 或高海拔 (HA) 后 4-7 小时进行了 103 +/- 6 W 的恒定工作负荷，对运动对与急性高山病 (AMS) 相关的液体潴留的可能影响进行了调查。在两个海拔高度运动期间和主动上升到 HA 期间的平均心率相似。在洛杉矶 4,559 m 的 3 天逗留期间，运动引起的变化在 8 名保持良好的受试者和 9 名发生 AMS 的受试者之间没有显着差异。 HA 时，运动前（71 +/- 2 对比 83 +/- 2%，P 小于 0.01）和运动期间（67 +/- 2 对比 72 +/- 1%，P 小于 0.025）氧饱和度较低，运动引起的血浆醛固酮（617 +/- 116 对比 233 +/- 42 pmol/l，P 小于 0.025）和血浆增加AMS 组的抗利尿激素水平较高（23.8 +/- 14.4 vs. 3.4 +/- 1.8 pmol/l，P 小于 0.05），而运动引起的血浆心房钠尿因子升高以及血浆血细胞比容、钾和渗透压的变化在两组中相似。（摘要截短为 250 字）
A possible contribution of exercise to the fluid retention associated with acute mountain sickness (AMS) was investigated in 17 mountaineers who underwent an exercise test for 30 min on a bicycle ergometer with a constant work load of 148 +/- 9 (SE) W at low altitude (LA) and with 103 +/- 6 W 4-7 h after arrival at 4,559 m or high altitude (HA). Mean heart rates during exercise at both altitudes and during active ascent to HA were similar. Exercise-induced changes at LA did not differ significantly between the eight subjects who stayed well and the nine subjects who developed AMS during a 3-day sojourn at 4,559 m. At HA, O2 saturation before (71 +/- 2 vs. 83 +/- 2%, P less than 0.01) and during exercise (67 +/- 2 vs. 72 +/- 1%, P less than 0.025) was lower and exercise-induced increase of plasma aldosterone (617 +/- 116 vs. 233 +/- 42 pmol/l, P less than 0.025) and plasma antidiuretic hormone (23.8 +/- 14.4 vs. 3.4 +/- 1.8 pmol/l, P less than 0.05) was greater in the AMS group, whereas exercise-induced rise of plasma atrial natriuretic factor and changes of hematocrit, potassium, and osmolality in plasma were similar in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)