International guidelines for the in vivo assessment of skin properties in non-clinical settings: Part 2. transepidermal water loss and skin hydration
International guidelines for the in vivo assessment of skin properties in non-clinical settings: Part 2. transepidermal water loss and skin hydration
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DOI：
10.1111/srt.12037
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发表时间：
2013-08-01
影响因子：
2.2
通讯作者：
Holness, Linn
中科院分区：
文献类型：
--
作者：
du Plessis, Johan;Stefaniak, Aleksandr;Holness, Linn
背景资料：有一种新的观点认为，仅仅评估皮肤在工作场所暴露于物理和化学应激源是不够的，评估暴露皮肤在暴露时的皮肤屏障功能也很重要。代表非临床环境的工作场所环境可能高度可变且难以控制，从而呈现出临床环境中通常不会遇到的独特测量挑战。方法：一个专家工作组召开了一次研讨会，作为第五届化学品皮肤职业和环境暴露国际会议（OEESC）的一部分，以制定基本准则和最佳做法。（基于现有的临床指南，已发表的数据，和自己的经验）在体内测量的经表皮水分损失（TEWL）和皮肤水合作用在非临床设置与具体参考工作场所作为最坏的情况scenaries.Results：这些指南的关键要素是：（i）在可行的情况下，尽量减少或认识到相关的内源性、外源性、环境和测量/仪器相关因素的影响;（ii）用封闭室型仪器测量TEWL;（iii）以差异或百分比变化报告结果（而不是绝对值）;和（iv）准确地报告任何明显偏离本指南。结论：预计这些指南将促进一致的数据报告，这将有利于相互比较的研究结果。
Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, representing a non-clinical environment, can be highly variable and difficult to control, thereby presenting unique measurement challenges not typically encountered in clinical settings.Methods: An expert working group convened a workshop as part of the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals (OEESC) to develop basic guidelines and best practices (based on existing clinical guidelines, published data, and own experiences) for the in vivo measurement of transepidermal water loss (TEWL) and skin hydration in non-clinical settings with specific reference to the workplace as a worst-case scenario.Results: Key elements of these guidelines are: (i) to minimize or recognize, to the extent feasible, the influences of relevant endogenous-, exogenous-, environmental- and measurement/instrumentation-related factors; (ii) to measure TEWL with a closed-chamber type instrument; (iii) report results as a difference or percent change (rather than absolute values); and (iv) accurately report any notable deviations from this guidelines.Conclusion: It is anticipated that these guidelines will promote consistent data reporting, which will facilitate inter-comparison of study results.