A major role for common genetic variation in anxiety disorders
A major role for common genetic variation in anxiety disorders
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DOI：
10.1038/s41380-019-0559-1
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发表时间：
2020-12-01
影响因子：
11
通讯作者：
Eley, Thalia C.
中科院分区：
文献类型：
--
作者：
Purves, Kirstin L.;Coleman, Jonathan R., I;Eley, Thalia C.
焦虑症是一种常见的、复杂的精神疾病，双胞胎遗传率为30- 60%。我们进行了终生焦虑症的全基因组关联研究（n（病例）=25 453，n（对照）=58 113）和当前焦虑症状的额外分析（n（病例）=19 012，n（对照）=58 113）。终身焦虑障碍的责任量表常见变异遗传率估计为26%，当前焦虑症状为31%。五个新的全基因组显着位点被确定，包括9号染色体上的一个基因间区域，以前与神经质，和一个位点重叠的BDNF受体基因，NTRK 2。焦虑与抑郁症、失眠症以及冠状动脉疾病有显著的正遗传相关性，这与流行病学研究的结果相吻合。我们的结论是，共同的遗传变异占焦虑的遗传结构的实质性比例。
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n(case)=25 453, n(control)=58 113) and an additional analysis of Current Anxiety Symptoms (n(case)=19 012, n(control)=58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.