Locus coeruleus lesions: Learning and extinction
Locus coeruleus lesions: Learning and extinction
复制标题
蓝斑病变：学习和消退
DOI：
10.1016/0031-9384(78)90296-2
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发表时间：
1978
影响因子：
2.9
通讯作者：
S. Mason
中科院分区：
文献类型：
--
作者：
G. Koob;A. Kelley;S. Mason
电解损毁双侧蓝斑核（LC）导致大脑皮质（85%）、海马（70%）和小脑皮质（83%）去甲肾上腺素大量耗竭，并导致获得食物奖励的L形跑道任务中断，但获得另一项学习任务，即同一装置中的空间辨别力未受损。收购其他两个操作性学习任务，食物奖励，杠杆压力反应和连续的视觉歧视，同样不受影响。在跑道或食物奖励，杠杆压力反应中没有发现灭绝行为的改变。LC大鼠更慢地习惯于在跑道上分散刺激，但没有差异，可以发现病变和假手术动物在光电池笼或在一个开放的领域的自发活动。这些结果与6-羟基多巴胺损伤后观察到的行为效应的中央被盖束的去甲肾上腺素途径的上升，并建议LC病变产生一个显着不同的配置文件的行为改变。
Bilateral destruction of the nucleus locus coeruleus (LC) by the electrolytic lesion produced large depletions of noradrenaline in the cerebral cortex (85%), hippocampus (70%), and cerebellar cortex (83%), and produced a disruption of the acquisition of an L-shaped runway task for food reward, however, acquisition of another learning task, a spatial discrimination in the same apparatus was not impaired. Acquisition of two other operant learning tasks, a food rewarded, lever press response and a successive visual discrimination, were similarly unaffected. No alteration in extinction behavior was found in the runway or in the food rewarded, lever press response. LC rats did habituate more slowly to distracting stimuli in the runway, but no difference could be found between the lesion and sham animals in locomotor activity in photocell cages or in an open field. These results are compared with the behavioral effects observed after 6-hydroxydopamine lesion to the ascending noradrenaline pathways of the central tegmental tract, and suggest that LC lesions produce a markedly different profile of behavioral alterations.