Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades
Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades
复制标题
富血小板血浆治疗不同程度雄激素性脱发的疗效
DOI：
10.1007/s40261-019-00806-4
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发表时间：
2019-09-01
影响因子：
3.2
通讯作者：
Hu, Zhiqi
中科院分区：
文献类型：
--
作者：
Qu, Qian;Shi, Panli;Hu, Zhiqi
背景与目的富血小板血浆（PRP）作为治疗雄激素源性脱发（阿加）的一种有价值的工具，已受到越来越多的关注。然而，缺乏关于PRP对男性型脱发（MPHL）和女性型脱发（FPHL）中不同等级阿加的具体有效性和满意度的知识。本研究的目的是确定和比较PRP治疗的疗效和安全性不同等级的阿加在男性和女性超过6 months.MethodsIn这项研究中，51 MPHL患者与诺伍德-汉密尔顿阶段II-V和42 FPHL患者路德维希阶段I至III参加了6个月的会议PRP注射。通过广义估计方程（GEE）模型，采用纵向分析比较MPHL和FPHL 6个月内的头发密度、厚度和头发拉拔试验。头皮炎症和油脂分泌，全球照片和整体患者satisfactions.ResultsConsequently，改善头发密度，头发厚度，头发拉力试验，头皮炎症和油脂分泌的水平观察与统计学意义的MPHL和FPHL在6个月的所有阶段。值得注意的是，较低水平的脱发（II级，III级MPHL和I级FPHL）有更好的反应PRP，也有一个更好的趋势，头发生长的增量比高级别的患者延长treatment.ConclusionsPRP注射，作为一种有效和可靠的治疗，可以推荐用于II级和III级MPHL和I级FPHL。
Background and ObjectivesPlatelet-rich plasma (PRP) has received growing attention as a valuable therapeutic tool in androgenetic alopecia (AGA). However, knowledge regarding specific effectiveness and satisfaction of PRP for different grades of AGA in male pattern hair loss (MPHL) and female pattern hair loss (FPHL) is missing. This study aims to ascertain and compare the efficacy and safety of PRP treatment for different grades of AGA in males and females over 6 months.MethodsIn this study, 51 MPHL patients with Norwood-Hamilton stage II-V and 42 FPHL patients with Ludwig stage I to III were enrolled for 6 monthly sessions of PRP injections. A longitudinal analysis was used to compare the hair density, thickness, and hair pull test over 6 months for MPHL and FPHL through generalized estimating equation (GEE) models. Phototrichograms of scalp inflammation and oil secretion, global photographs and overall patient satisfaction were also assessed.ResultsConsequently, improvement of hair density, hair thickness, hair pull test, the level of scalp inflammation and oil secretion were observed with statistical significance in all stages for both MPHL and FPHL at 6 months. Noteworthy, lower level of alopecia (Grade II, III in MPHL and Grade I in FPHL) had better response to PRP, and also had a better tendency of increment of hair growth than that of high-grade patients with prolonged treatment.ConclusionsPRP injections, as an efficacious and reliable therapy, can be recommended for Grade II and Grade III in MPHL and Grade I in FPHL.