Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer
Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer
复制标题
使用基于锑烯的 X 射线放射增敏剂进行超有效的癌症治疗
DOI：
10.1002/adfm.201906010
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发表时间：
2020-01-01
影响因子：
19
通讯作者：
Zhang, Han
中科院分区：
文献类型：
--
作者：
Duo, Yanhong;Huang, Yanyu;Zhang, Han
纳米颗粒化疗药物具有诱导活性氧（ROS）过量产生和发挥抗缺氧作用以实现有效癌症放射治疗的巨大潜力。然而，以前设计智能放射增敏剂的策略需要多步掺入纳米材料以实现有价值的放射敏感性结果，这会导致不可预测的安全问题，包括分解不良和不确定的生物转化。超薄锑烯纳米颗粒（AMNPs）被证明是一种新的放射增敏剂，通过诱导强烈的氧化应激反应和显着高的放射毒性，在体内实现有效的放射化疗效果。分析AMNPs的辐照过程表明，辐照加速了光电子的产生和向毒性Sb2O3的价态转变，导致癌细胞凋亡和S期阻滞。AMNP在黑色素瘤小鼠模型中的肿瘤消退活性和隐藏的生物毒性增强了锑烯通过增加ROS产生和常氧来克服辐射抗性的适用性。这一新技术可以扩展锑烯作为一种有效的放射增敏剂的应用，并可以促进其在未来的可调和有效的放射增敏临床转化。
Nanoparticulate chemotherapeutics hold great potential for inducing reactive oxygen species (ROS) overproduction and exerting antihypoxic effects for efficient cancer radiotherapy. However, previous strategies for designing smart radiosensitizers necessitate the multistep incorporation of nanomaterials to achieve valuable radiosensitive outcomes, which causes unpredictable safety issues including poor decomposition and undefined biotransformations. Ultrathin antimonene nanoparticles (AMNPs) are demonstrated as new radiosensitizers that achieve an efficient radiochemotherapeutic effect through the induction of a strong oxidative stress response and their significantly high radiotoxicity in vivo. Analyzing the irradiation process of AMNPs indicates that irradiation accelerates photoelectron generation and the valence transition to toxic Sb2O3, leading to cancer cell apoptosis and S‐phase arrest. The tumor regression activity and concealed biotoxicity of the AMNPs in a melanoma mouse model enhance the applicability of antimonene to overcoming radioresistance by increasing ROS generation and normoxia. This new technology can extend the applications of antimonene as an effective radiosensitizer and can promote its clinical translation for tunable and effective radiosensitization in the future.