Dietary nucleotides: a novel supplement in fish feeds 1. Effects on resistance to disease in salmonids
Dietary nucleotides: a novel supplement in fish feeds 1. Effects on resistance to disease in salmonids
复制标题
DOI：
10.1016/s0044-8486(01)00577-4
复制
发表时间：
2001-07-16
期刊：
影响因子：
4.5
通讯作者：
Forno, PF
中科院分区：
文献类型：
--
作者：
Burrells, C;Williams, PD;Forno, PF
为了确定在水产养殖饲料中添加外源核苷酸对鱼类对各种挑战感染的抵抗力的影响，进行了试验并给出了结果。当添加到普通鱼类饲料配方中时，这些额外的核苷酸被证明以0.03%的组合包含率提高了对细菌攻击感染的抵抗力。病毒和立克次体疾病以及体外寄生虫病。当在激发前喂养3周时，添加核苷酸的饲料(31%的死亡率：相对存活率：RPS=37%)优于含有β-葡聚糖的饲料(43%的死亡率；RPS=12%)，以减少投喂对照饲料的鱼因鳗弧菌感染而引起的死亡率(49%)。感染传染性鲑鱼贫血病毒和鲑鱼的死亡率也显著降低(RPS分别为25.7%和42.1%)，海虱的数量也显著减少(平均每条鱼附着的虱子数量减少37.8%)。讨论了补充饮食核苷酸的作用模式和相对于公认的免疫刺激剂的优势。(C)2001 Elsevier Science B.V.保留所有权利。
To determine the effects of the inclusion of exogenous nucleotides in aquaculture diets on the resistance of fish to various challenge infections, trials were carried out and results presented. When added to normal fish feed formulations at a combined inclusion level of 0.03%, these additional nucleotides were shown to increase resistance to challenge infections with bacterial. viral and rickettsial diseases as well as ectoparasitic infestation. When fed for 3 weeks prior to challenge, the nucleotide-supplemented diet was superior (31% mortalities: relative percent survival: RPS = 37%) to a beta -glucan-containing diet (43% mortalities; RPS = 12%) in reducing mortalities due to Vibrio anguillarum infection in fish fed the control diet (49% mortalities). Mortalities resulting from infections with infectious salmon anaemia (ISA) virus and Piscirickettsia salmonis were also significantly reduced (RPS = 25.7% and 42.1%, respectively) as were the numbers of infesting sea lice (Lepeophtheirus salmonis) (37.8% reduction in the mean number of attached lice per fish). The mode of action of supplemental dietary nucleotides and advantages over recognised immunostimulants are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.