Developmental origin of wiring specificity in the olfactory system of Drosophila
Developmental origin of wiring specificity in the olfactory system of Drosophila
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DOI：
10.1242/dev.00896
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发表时间：
2004-01-01
期刊：
影响因子：
4.6
通讯作者：
Luo, LQ
中科院分区：
文献类型：
--
作者：
Jefferis, GSXE;Vyas, RM;Luo, LQ
在昆虫和哺乳动物中，表达特定嗅觉受体的嗅觉受体神经元（ORN）将其轴突聚集到特定的肾小球上，在大脑中创建空间地图。我们先前已经证明，果蝇的二级投射神经元（PN）是由谱系和出生顺序预先指定的，将它们的树突发送到触角叶中类似于50个肾小球中的一个。一种给定的ORN轴突如何与一种给定的PN树突相匹配？在这里，我们研究导致这种布线特异性的细胞和发育事件。我们发现，在ORN轴突到达之前，PN树突已经创建了一个类似于成人肾小球地图的原型地图，凭借其选择性树突定位。位置线索，创建这个原型树突地图似乎不是从残留的幼虫嗅觉系统或触角叶内的神经胶质过程。相反，我们建议，这种原型地图可能起源于图案信息外部的发展触角叶和PN树突之间的相互作用。
In both insects and mammals, olfactory receptor neurons (ORNs) expressing specific olfactory receptors converge their axons onto specific glomeruli, creating a spatial map in the brain. We have previously shown that second order projection neurons (PNs) in Drosophila are prespecified by lineage and birth order to send their dendrites to one of similar to50 glomeruli in the antennal lobe. How can a given class of ORN axons match up with a given class of PN dendrites? Here, we examine the cellular and developmental events that lead to this wiring specificity. We find that, before ORN axon arrival, PN dendrites have already created a prototypic map that resembles the adult glomerular map, by virtue of their selective dendritic localization. Positional cues that create this prototypic dendritic map do not appear to be either from the residual larval olfactory system or from glial processes within the antennal lobe. We propose instead that this prototypic map might originate from both patterning information external to the developing antennal lobe and interactions among PN dendrites.