Calcium exchange hypothesis of skeletal muscle fatigue: a brief review.
Calcium exchange hypothesis of skeletal muscle fatigue: a brief review.
复制标题
骨骼肌疲劳的钙交换假说：简要回顾。
DOI：
10.1002/mus.880180409
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Klug,GA
中科院分区：
文献类型：
--
作者：
Williams,JH;Klug,GA
Skeletal muscle fatigue is often associated with diminished athletic performance and work productivity as well as increased susceptibility to injury. The exact cause of muscle fatigue probably involves a number of factors which influence force production in a manner dependent on muscle fiber type and activation pattern. However, a growing body of evidence implicates alterations in intracellular Ca2+exchange as a major role in the fatigue process. These changes are thought to occur secondary to reductions in the rates of Ca2+uptake and release by the sarcoplasmic reticulum (SR). This hypothesis is based on the finding that peak myoplasmic Ca2+concentration ([Ca2+]i) is reduced as force declines during fatigue. In addition, direct measurements of Ca2+uptake and release show that fatiguing activity causes intrinsic alterations in the functional properties of the SR. We also propose that fatigue‐induced alterations in Ca2+exchange may be beneficial, reducing the rate of energy utilization by the muscle fiber and preventing irreversible damage to the cell. © 1995 John Wiley & Sons, Inc.
