Differences in the interaction of HIV-1 and HIV-2 with CD4.
Differences in the interaction of HIV-1 and HIV-2 with CD4.
复制标题
HIV-1 和 HIV-2 与 CD4 相互作用的差异。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
H. Mitsuya
中科院分区：
文献类型：
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作者：
David J. Looney;S. Hayashi;M. Nicklas;Redfield Rr;S. Broder;F. Wong;H. Mitsuya
Inhibition of infectivity, cytopathicity, and binding by soluble CD4 was determined for several human immunodeficiency virus (HIV)-1 and HIV-2 strains. Although infectivity and binding of both groups were blocked equally well by OKT4A, HIV-2 viruses were more refractory to inhibition by soluble CD4. Rates of envelope shedding, as determined by thermal stability, did not differ between HIV-1 and HIV-2; however, Scatchard plot analysis of radiolabeled virus binding revealed that fewer HIV-2 virions were bound to CD4+ cells under saturating conditions. The HIV-2 viruses also possessed consistently greater infectivity, whereas greater concentrations of gp120 were found in supernatants of HIV-1-infected cells and in HIV-2 virus pellets, suggesting that more envelope glycoprotein remains associated with HIV-2 virions. This factor may contribute to the observed in-vitro resistance of HIV-2 viruses to soluble CD4.
