'Food addiction' and its association with a dopaminergic multilocus genetic profile
'Food addiction' and its association with a dopaminergic multilocus genetic profile
复制标题
DOI：
10.1016/j.physbeh.2013.05.014
复制
发表时间：
2013-06-13
影响因子：
2.9
通讯作者：
Kennedy, James L.
中科院分区：
文献类型：
--
作者：
Davis, Caroline;Loxton, Natalie J.;Kennedy, James L.
背景：我们的目标是在食物成瘾研究中采用一种新颖的遗传学方法，通过聚合多巴胺途径的功能变异来反映多基因倾向。我们预计多巴胺信号传导的综合指数（多位点遗传谱评分[MLGP]）将区分那些被指定为食物成瘾的人（根据耶鲁大学食物成瘾量表[YFAS]标准）以及年龄和体重相当的对照。我们的第二个目标是评估该指数是否与食物成瘾的饮食相关亚表型（例如暴饮暴食和食物渴望）呈正相关。方法：从社区招募成年人（n = 120）进行暴饮暴食/超重研究。完成饮食行为问卷并采集血样进行基因分型。结果和结论：YFAS 确定了 21 名参与者患有食物成瘾。正如预测的那样，经 YFAS 诊断为食物成瘾的人的 MLGP 得分较高，并且与暴饮暴食、对食物的渴望和情绪性暴饮暴食呈正相关。然后，我们测试了多重中介模型，提出奖励驱动的暴饮暴食促进了 MLGP 分数与食物成瘾之间的关系。该模型具有统计学意义，支持这样的观点：多巴胺信号传导的复合遗传指数与食物成瘾之间的关系是由奖励反应性暴饮暴食的某些方面介导的。 (C) 2013 Elsevier Inc. 保留所有权利。
Background: Our objective was to employ a novel genetic methodology - whereby functional variants of the dopamine pathway were aggregated to reflect a polygenic liability - in the study of food addiction. We anticipated that the composite index of elevated dopamine signaling (a multilocus genetic profile score [MLGP]) would distinguish those with a designation of food addiction (according to the Yale Food Addiction Scale [YFAS] criteria), and age and weight equivalent controls. Our second aim was to assess whether this index was positively associated with eating-related sub-phenotypes of food addiction (e.g. binge eating and food cravings).Methods: Adults (n = 120) recruited from the community were solicited for an overeating/overweight study. Eating-behavior questionnaires were completed and a blood sample was taken for genotyping.Results and conclusions: The YFAS identified 21 participants with food addiction. As predicted, the MLGP score was higher in those with YFAS-diagnosed food addiction, and it correlated positively with binge eating, food cravings, and emotional overeating. We then tested a multiple-mediation model proposing that reward-driven overeating facilitates the relationship between the MLGP score and food addiction. The model was statistically significant, supporting the view that the relationship between a composite genetic index of dopamine signaling and food addiction is mediated by certain aspects of reward-responsive overeating. (C) 2013 Elsevier Inc. All rights reserved.