The Effect of Xenon on Isoflurane Protection Against Experimental Myocardial Infarction
The Effect of Xenon on Isoflurane Protection Against Experimental Myocardial Infarction
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DOI：
10.1053/j.jvca.2009.01.028
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发表时间：
2009-10-01
影响因子：
2.8
通讯作者：
Rossaint, Rolf
中科院分区：
文献类型：
--
作者：
Baumert, Jan H.;Hein, Marc;Rossaint, Rolf
目的：研究氙气和异氟烷对心肌缺血再灌注损伤的保护作用是否是additional.Design：前瞻性，随机实验室调查。设置：一所大学医院的动物实验室。参与者：36只猪（女性德国长白猪）。干预：在开胸准备硫喷妥钠麻醉，左前降支动脉闭塞，产生缺血60分钟。1小时前，在各组中开始缺血预处理、单独使用异氟烷（0.55最小肺泡浓度[MAC]）或异氟烷与氙气（各0.55 MAC）联合使用。第四组（对照组）没有接受保护性干预。心肌缺血后2小时的reperfusion. Measures和主要结果：心脏被切除和染色（伊文思蓝/TTC），以测量梗死面积的相关领域的风险。心肌梗死面积减少（平均值+/-标准差），从对照组危险面积的64% +/- 9%减少到缺血预处理的19% +/-12%，异氟烷的46% +/- 12%，异氟烷和氙的39% +/- 13%。结论：异氟醚/氙联合麻醉可降低脑梗死面积，但与单用异氟醚相比，差异无统计学意义。缺血预处理的效果优于麻醉药。(C)2009爱思唯尔公司版权所有
Objectives: To investigate if the protective effects of xenon and isoflurane against myocardial ischemia-reperfusion damage would be additive.Design: A prospective, randomized laboratory investigation.Setting: An animal laboratory of a university hospital.Participants: Thirty-six pigs (female German landrace).Interventions: In an open-chest preparation with thiopental anesthesia, the left anterior descending artery was occluded to produce ischemia for 60 minutes. One hour previously, ischemic preconditioning, isoflurane (0.55 minimum alveolar concentration [MAC]) alone, or isoflurane together with xenon (0.55 MAC each) were started in the respective groups. A fourth (control) group received no protective intervention. Myocardial ischemia was followed by 2 hours of reperfusion.Measurements and Main Results: Hearts were excised and stained (Evans Blue/TTC) to measure infarct size as related to the area at risk. Myocardial infarct size was reduced (means +/- standard deviation) from 64% +/- 9% of the area at risk in the control group to 19% +/- 12% with ischemic preconditioning to 46% +/- 12% with isoflurane and to 39% +/- 13% with isoflurane and xenon. All intervention groups were significantly different from the control (p < 0.05), and both anesthetic groups were significantly different from ischemic preconditioning (p < 0.05).Conclusion: Combined isoflurane/xenon anesthesia reduced infarct size but not more than isoflurane alone. Ischemic preconditioning was more effective than the anesthetics. (C) 2009 Elsevier Inc. All rights reserved