Expression of insulin-like growth factor-II mRNA in fetal kidney and Wilms' tumor. An in situ hybridization study.
Expression of insulin-like growth factor-II mRNA in fetal kidney and Wilms' tumor. An in situ hybridization study.
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胎儿肾和肾母细胞瘤中胰岛素样生长因子-II mRNA 的表达。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
D. Yee
中科院分区：
文献类型：
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作者：
S. Paik;N. Rosen;W. Jung;J. You;M. Lippman;J. Perdue;D. Yee
用原位杂交技术检测了肾发育过程中胰岛素样生长因子Ⅱ（IGF-II）mRNA的表达。在发育中的肾脏，IGF-II主要表达在胚基细胞中，并随着其分化而丢失。在三相性肾母细胞瘤中也发现类似的关系，但在单形性肾母细胞瘤中，上皮分化的肿瘤细胞表达IGF-II mRNA。这些数据表明，IGF-II可能参与胎儿肾发生，它的表达是反向耦合到正常上皮分化，这种分化可能是异常调节肾母细胞瘤。
The pattern of insulin-like growth factor II (IGF-II) mRNA expression in developing kidney and Wilms' tumor was examined with in situ hybridization. In developing kidney, IGF-II was primarily expressed in blastemal cells and lost with their differentiation. In triphasic Wilms' tumor, a similar relationship was found. But in a monomorphous Wilms', tumor cells with epithelial differentiation expressed IGF-II mRNA. These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.