Peripheral neuropathy after exposure to an ester of dichlorophenoxyacetic acid.
Peripheral neuropathy after exposure to an ester of dichlorophenoxyacetic acid.
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接触二氯苯氧基乙酸酯后发生周围神经病变。
DOI：
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发表时间：
1959
影响因子：
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通讯作者：
J. Brown
中科院分区：
文献类型：
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作者：
N. Goldstein;P. H. Jones;J. Brown
三名患者（一名52岁男性、一名50岁女性和一名65岁男性）因严重的感觉和运动症状而需要住院治疗。在每例病例中，这种疾病都是在使用二氯苯氧乙酸（2，4-D）制剂杀死杂草几小时后开始的;症状在几天内持续发展，直到疼痛、感觉异常和瘫痪严重。残疾是长期的，甚至在几年之后也没有完全恢复。毫无疑问，溢出的2，4-D的经皮吸收造成了神经损伤。肌电图检查支持周围神经病变的诊断。由于2，4-D中毒没有解毒剂或其他特定治疗方法，因此应谨慎使用这种除草剂。
Severe sensory and motor symptoms necessitated hospitalization of three patients, a 52-year-old man, a 50-year-old woman, and a 65-year-old man. In each case the disorder began some hours after the use of preparations of dichlorophenoxyacetic acid (2,4-D) to kill weeds; the symptoms progressed through a period of days until pain, paresthesias, and paralysis were severe. Disability was protracted, and recovery was incomplete even after the lapse of years. There was little doubt that the neurological damage was done by the percutaneous absorption of spilled 2,4-D. The electromyographic examination supported the diagnosis of peripheral neuropathy. Since there is no antidote or other specific treatment for 2,4-D poisoning, this herbicide should be used with caution.